Novel atypical G protein signal transduction regulator homologous domain

Through structural biology, Liu Jinsong's research group at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, discovered a novel class of atypical G protein signal transduction regulators (RGS) homologous domains (RGS homology, RH) in sorted transporters (SNXs).

As the first transshipment sorting station of the endocytic pathway, the connotation is considered an important platform
for signal transduction.

In order to better understand the function of the RH domain of SNX-RH protein, the research group conducted structural biology research
on the RH domain of SNX-RH protein.

This study provides a structural basis
for the study of the functional mechanism of SNX-RH subfamily proteins.

Zhang Yulong, a doctoral student at Guangzhou Health Institute, is the first author, and Xu Jinxin and Liu Jinsong are co-corresponding authors
.

Crystal structure and homodimer formation in SNX13 and SNX25RH domains

Links to papers