npj Parkinson's Disease: Non-invasive vagus nerve stimulation can improve clinical and molecular biomarkers in patients with Parkinson's disease with gait freezing

Non-invasive vagus nerve stimulation (nVNS) is a recognized treatmentmedsci.

medsci.

npj Parkinsons Dis npj Parkinsons Dis magazine .

In a group of patients, they measured selected neurotrophic factor levels and markers of inflammation and oxidative stress in the serum before and after the experimental intervention.

Compared with the sham stimulation group, nVNS has significant improvement in key gait parameters, including walking speed, standing time and step length .

Compared with the sham stimulation group, nVNS has significant improvements in key gait parameters, including walking speed, standing time and step length.

Similarly, the overall motor function (MDS-UPDRS III) after nVNS stimulation was also significantly improved.

The overall motor function (MDS-UPDRS III) was also significantly improved after nVNS stimulation.

Serum tumor necrosis factor (TNF)-α and glutathione levels were significantly reduced after nVNS treatment, and brain-derived neurotrophic factor (BDNF) levels were significantly increased (p<0.

Serum tumor necrosis factor (TNF)-α and glutathione levels were significantly reduced after nVNS treatment, and brain-derived neurotrophic factor (BDNF) levels were significantly increased (p<0.

The study provides preliminary evidence for the effectiveness and safety of nVNS in the treatment of motor and non-motor symptoms of Parkinson’s disease.

Mondal, B.

Mondal, B.
, Choudhury, S.
, Banerjee, R.
et al.
 Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson's disease in patients with freezing of gait.
  npj Parkinsons Dis.
 7,  46 (2021).
https ://doi.
org/10.
1038/s41531-021-00190-x Mondal, B.
, Choudhury, S.
, Banerjee, R.
  et al.
npj Parkinsons Dis.
7, 

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