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Editor’s note iNature is China’s largest academic official account.
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us
.
iNature marmosets are highly socialized non-human primates
.
They exhibit abundant vocalization, but the neural basis behind complex vocal communication is largely unknown
.
On July 12, 2021, Pu Muming and Wang Liping from the Institute of Neurobiology of the Chinese Academy of Sciences published an online report entitled "Distinct neuron populations for simple and compound calls in the primary auditory cortex of awake marmosets" in National Science Review (IF=17.
27).
A research paper that reports the existence of specific neuronal groups in the marmoset A1, which selectively respond to different simple or compound calls from the same species of marmoset
.
These neurons are spatially dispersed within A1, but are different from those that respond to pure tones
.
When a single domain of the call is deleted or the domain sequence is changed, the call selective response is significantly reduced, indicating the importance of the global rather than local spectrum-time properties of the sound
.
When the order of the two simple call components is reversed or the interval between them is extended by more than 1 second, the selective response to the composite call will also disappear
.
Mild anesthesia largely eliminates the selective response to calling
.
In summary, the results of this study demonstrate a wide range of inhibitory and facilitation interactions between call-evoked responses, and provide a basis for further research on the neural circuit mechanisms behind voice communication in awake non-human primates
.
The marmoset is considered to be an excellent animal model for studying the neural matrix behind complex acoustic communication
.
Previous brain imaging and electrophysiological studies of the primate auditory system have shown that neurons in the frontal and temporal lobes show a high preference for complex sounds, while neurons located in more tail regions (such as the primary auditory cortex (A1)) Known for its tonal properties, neurons are clustered in areas that prefer specific frequencies
.
In addition to frequency preference, A1 neurons are also sensitive to specific spectral-time characteristics of sound, such as harmonics, frequency, and time modulation
.
Electrophysiological studies of anesthetized marmoset A1 detected that neurons selectively respond to simple Twitter calls
.
However, it is not clear whether A1 neurons can selectively respond to all natural calls, including simple calls and compound calls, and whether the call-evoked response is only due to the characteristics of neurons that are sensitive to specific local spectrum-time sounds or require different This kind of global time organization of sound components, such as the sequence and interval of simple calling components in a compound call
.
Therefore, it is important to simultaneously record the activity of the large A1 neuron population in the same marmoset
.
This recording needs to be done in an awake state, because anesthesia is known to greatly reduce neuronal activity in the cortex
.
In this study, two-photon fluorescence imaging was performed on a large number of A1 neurons in unanaesthetized marmosets by acute loading of the Ca2+ sensitive fluorescent dye Cal-520AM
.
This method allows rapid labeling of a larger percentage of neurons than can currently be achieved by GCaMP6 gene expression
.
Using this method, the study has determined that these neurons selectively respond to different simple and compound calls of the same kind in the traditional tonal region of a large number of neurons in A1, but do not respond to pure tones
.
Further research on selective neurons for compound calling shows that their responses are sensitive to the sequence and interval of simple calling components, and the characteristics of vocal processing
.
These selective responses to compound calls are only for naturally occurring compound calls rather than artificially constructed compound calls, and are completely eliminated by mild anesthesia
.
These findings confirmed the existence of a large number of call-selective neuron groups in the A1 of awake marmosets, indicating that the early sound processing of the auditory system is very complicated
.
Reference message: https://academic.
oup.
com/nsr/advance-article/doi/10.
1093/nsr/nwab126/6319506?searchresult=1
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us
.
iNature marmosets are highly socialized non-human primates
.
They exhibit abundant vocalization, but the neural basis behind complex vocal communication is largely unknown
.
On July 12, 2021, Pu Muming and Wang Liping from the Institute of Neurobiology of the Chinese Academy of Sciences published an online report entitled "Distinct neuron populations for simple and compound calls in the primary auditory cortex of awake marmosets" in National Science Review (IF=17.
27).
A research paper that reports the existence of specific neuronal groups in the marmoset A1, which selectively respond to different simple or compound calls from the same species of marmoset
.
These neurons are spatially dispersed within A1, but are different from those that respond to pure tones
.
When a single domain of the call is deleted or the domain sequence is changed, the call selective response is significantly reduced, indicating the importance of the global rather than local spectrum-time properties of the sound
.
When the order of the two simple call components is reversed or the interval between them is extended by more than 1 second, the selective response to the composite call will also disappear
.
Mild anesthesia largely eliminates the selective response to calling
.
In summary, the results of this study demonstrate a wide range of inhibitory and facilitation interactions between call-evoked responses, and provide a basis for further research on the neural circuit mechanisms behind voice communication in awake non-human primates
.
The marmoset is considered to be an excellent animal model for studying the neural matrix behind complex acoustic communication
.
Previous brain imaging and electrophysiological studies of the primate auditory system have shown that neurons in the frontal and temporal lobes show a high preference for complex sounds, while neurons located in more tail regions (such as the primary auditory cortex (A1)) Known for its tonal properties, neurons are clustered in areas that prefer specific frequencies
.
In addition to frequency preference, A1 neurons are also sensitive to specific spectral-time characteristics of sound, such as harmonics, frequency, and time modulation
.
Electrophysiological studies of anesthetized marmoset A1 detected that neurons selectively respond to simple Twitter calls
.
However, it is not clear whether A1 neurons can selectively respond to all natural calls, including simple calls and compound calls, and whether the call-evoked response is only due to the characteristics of neurons that are sensitive to specific local spectrum-time sounds or require different This kind of global time organization of sound components, such as the sequence and interval of simple calling components in a compound call
.
Therefore, it is important to simultaneously record the activity of the large A1 neuron population in the same marmoset
.
This recording needs to be done in an awake state, because anesthesia is known to greatly reduce neuronal activity in the cortex
.
In this study, two-photon fluorescence imaging was performed on a large number of A1 neurons in unanaesthetized marmosets by acute loading of the Ca2+ sensitive fluorescent dye Cal-520AM
.
This method allows rapid labeling of a larger percentage of neurons than can currently be achieved by GCaMP6 gene expression
.
Using this method, the study has determined that these neurons selectively respond to different simple and compound calls of the same kind in the traditional tonal region of a large number of neurons in A1, but do not respond to pure tones
.
Further research on selective neurons for compound calling shows that their responses are sensitive to the sequence and interval of simple calling components, and the characteristics of vocal processing
.
These selective responses to compound calls are only for naturally occurring compound calls rather than artificially constructed compound calls, and are completely eliminated by mild anesthesia
.
These findings confirmed the existence of a large number of call-selective neuron groups in the A1 of awake marmosets, indicating that the early sound processing of the auditory system is very complicated
.
Reference message: https://academic.
oup.
com/nsr/advance-article/doi/10.
1093/nsr/nwab126/6319506?searchresult=1
