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iNature
Salmonella enterica is one of the
most common bacterial pathogens in humans and animals.
The trend and geographical distribution of drug-resistant Salmonella and dominant serovariants have been systematically studied in Europe and the United States, while relevant studies
have not been carried out in China.
On November 29, 2022, Zhu Baoli, Gao Fu, and Xu Xuebin, from the Institute of Microbiology of the Chinese Academy of Sciences, jointly published an online report entitled "The temporal dynamics of antimicrobial-resistant-Salmonella enterica and" in the National Science Review (IF=23).
Predominant Serovars in China", which reveals the temporal dynamics
of drug-resistant enteric salmonella and major serovariants in China.
In this study, the "One Health" strategy was used to study
the spatiotemporal dynamics of the dominant serovariant in China using > 35,000 strains of Salmonella enterica.
The study found that in China, Salmonella typhimurium is the main serum virus that causes human infections, which is consistent with Australia and inconsistent
with North American and European countries.
The authors randomly selected 1962 isolates to compare genomics and antimicrobial resistance studies and found that over a 14-year period, each isolate had 1.
84 and 2.
69 times
more antibiotic resistance genes (ARGs) than human and non-human sources, respectively.
From 2006 to 2019, the proportion of drug-resistant Salmonella strains showed an upward trend, especially the proportion of β-lactams, quinolones, tetracyclines and
rifampicin-resistant strains.
In addition, we found a higher diversity of sequence types (STs) of plague compared to other serums, with ST34 from pigs and ST19 from chickens associated
with isolates that cause stomach infections in children and adults, respectively.
The results of this study fill the data gap
of dominant serovariants and drug resistance trends of Salmonella enterica in China.
These data provide useful information
for public health decision-makers prioritizing foodborne illness and food safety interventions.
Salmonella enterica is the leading cause of foodborne illness worldwide, and antibiotic-resistant Salmonella enterica isolates pose a serious threat
to public health.
Salmonella enterica consists of 11 subspecies
.
Subspecies Salmonella enteritidis typhi (S.
typhi) and S.
paratyphi A, B or C can cause typhoid and paratyphoid fever in humans, collectively known as enteric fever, while other serovariants are roughly described as non-Typhi Salmonella (NTS).
Previous studies have shown that from 1951 to 2007, a total of 322 serotypes
were detected in China.
In recent years, S.
Telkebier, S.
Telkebier, S.
Uzaramo and S.
Telkebier.
Changwananni was discovered in China by his research colleagues, and they were all identified and reported
for the first time abroad.
Although previous meta-analyses have provided a good summary of the prevalence and diversity of Salmonella in five continents (Africa, Americas, Asia, Europe, and Oceania), there are no systematic studies
of the epidemiology and spatiotemporal dynamics of the dominant serovariant of Salmonella in China 。 To fill this data gap, the study systematically analyzed the characteristics of 35,000 strains of >Enterococcus isolated from human and non-human sources registered in the database of Salmonella local surveillance systems (also known as the Bacterial Learning Alliance) of 23 provinces or municipalities in China over a 14-year period.
Enterica's basic research and public health risk prediction support
.
Temporal and spatial changes of antimicrobial resistance in NTS in China (National Science Review) The emergence and spread of antibiotic resistance (AMR) in the Enterobacteriaceae family pose a serious threat to human and animal health
.
Notably, fluoroquinolone-resistant Salmonella and Enterobacteriaceae, which produce ultra-broad-spectrum β-lactamase (ESBL), were classified by WHO as high priority pathogens that pose a risk to human health in 2017, requiring research and development of new antibiotics
.
It is estimated that a sustained rise in antibiotic resistance by 2050 will lead to 10 million deaths per year and a reduction in GDP of 2-3.
5%.
This work provides the first systematic overview of trends in serovariant prevalence and resistance of Streptococcus enterococci isolated from human and non-human origin in China
.
S.
Typhimurium, S.
Enteritidis and S.
Typhimurium.
Derby is the main pathogen
of Chinese infections.
Together, the findings represent the largest longitudinal surveillance system for Enterococcus in China and provide valuable public health knowledge
about trends and distribution of Enterococcus serovariants and AMR.
This large-scale observational study will provide valuable information
for food safety intervention, control and prevention of the development and spread of drug-resistant Salmonella in China.
Original link: https://doi.
org/10.
1093/nsr/nwac269—END—content is [iNature].
