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    Home > Biochemistry News > Biotechnology News > Nutritional Value of d-Amino Acids, d-Peptides, and Amino Acid Derivatives in Mice

    Nutritional Value of d-Amino Acids, d-Peptides, and Amino Acid Derivatives in Mice

    • Last Update: 2021-02-28
    • Source: Internet
    • Author: User
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    This paper describes a method for determining the nutritional value of
    d

    -amino acids,
    d

    -peptides, and amino acid derivatives using a growth assay in mice fed a synthetic all-amino acid diet. A large number of experiments were carried out in which a molar equivalent of the test compound replaced a nutritionally essential amino acid such as
    l

    -lysine (
    l

    -Lys),
    l

    -methionine (
    l

    -Met),
    l

    -phenylalanine (
    l

    -Phe), and
    l

    -tryptophan (
    l

    -Trp) as well as the semi-essential amino acids
    l

    -cysteine (
    l

    -Cys) and
    l

    -tyrosine (
    l

    -Tyr). The results show wide-ranging variations in the biological utilization of test substances. The method is generally applicable to the determination of the biological utilization and safety of any amino acid derivative as a potential nutritional source of the corresponding
    l

    -amino acid. Because the organism is forced to use the
    d

    -amino acid or amino acid derivative as the sole source of the essential or semi-essential amino acid being replaced, and because a free amino acid diet allows better control of composition, the use of all-amino acid for such determinations may be preferable to protein-based diets.
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