Obesity increases the risk of gum disease

Obesity increases the risk of gum disease

Obesity increases the risk of gum disease Obesity increases the risk of gum disease

According to a new study by American scientists, chronic inflammation caused by obesity may trigger the development of cells that destroy bone tissue, including bones that fix teeth
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This study attempts to deepen the understanding of the link between obesity and gum disease, and the results were published in the Journal of Dental Research

Studies have found that excessive inflammation caused by obesity will increase the number of suppressive cells (MDSC) from the bone marrow, which are immune cells that increase during illness to regulate immune function
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MDSC originates in the bone marrow and can develop into a series of different types of cells, including osteoclasts (a cell that breaks down bone tissue)

Osteoporosis is the main symptom of gum disease, which may eventually lead to tooth loss
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According to data from the US Centers for Disease Control and Prevention, periodontal disease affects more than 47% of adults aged 30 and over

"Although there is a clear relationship between obesity and periodontal disease, the mechanisms supporting these links are not very clear
.

" said Keith Kirkwood, professor of oral biology at the School of Dentistry, State University of New York at Buffalo

"This study puts forward the concept that MDSC during obesity will become osteoclasts during periodontitis, which is associated with increased alveolar bone damage
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In general, these data support that obesity will increase periodontal Views on the risk of bone loss

The researchers conducted a 16-week study on two groups of mice with completely different diets.
One group was a low-fat diet group, with 10% of energy coming from fat; the other group was a high-fat diet group, with 45% of energy coming from fat.

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The study found that compared with the low-fat diet group, mice in the high-fat diet group had more obesity, more inflammation, and increased bone marrow and spleen MDSCs
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The number of osteoclasts in the mice on the high-fat diet increased significantly, and the loss of alveolar bone (the bone that holds the teeth) was greater

In addition, in the high-fat diet group, the expression of 27 genes related to osteoclast formation was also significantly increased
.

Kirkwood said these findings may further clarify the mechanisms of other chronic inflammation and bone-related diseases that occur at the same time as obesity, such as arthritis and osteoporosis
.

(Source: China Science News Wen Lele)

Related paper information: https://doi.

https://doi.
org/10.
1177/00220345211040729 https://doi.
org/10.
1177/00220345211040729