Oncogene: Genomic characteristics and potential therapeutic targets of gastric liver-like adenocarcinoma

Hepatoid adenocarcinoma of the stomach (HAS) is a very rare but highly malignant gastric tumor in clinical practice

Figure 1: Research strategy for gastric liver-like adenocarcinoma

Researchers conducted multi-omics joint analysis on gastric hepatoid adenocarcinoma, and comprehensively applied exon sequencing, transcriptome sequencing and single-cell transcriptome sequencing methods, and completed 58 tumor tissues of 55 patients with gastric hepatoid adenocarcinoma.

Figure 2: Monoclonal origin characteristics of gastric liver-like adenocarcinoma

In order to further explore the gene expression characteristics of gastric liver-like adenocarcinoma, the researchers systematically compared the expression profiles of gastric liver-like adenocarcinoma with gastric adenocarcinoma and hepatocellular carcinoma

Figure 3: Gene expression characteristics of gastric liver-like adenocarcinoma

Finally, using single-cell transcriptome research methods, the researchers conducted a preliminary exploration of the tumor microenvironment of gastric-hepatoid adenocarcinoma and discovered the complex cell differentiation characteristics of gastric-hepatoid adenocarcinoma (Figure 4)

Figure 4: The complex cell differentiation characteristics and tumor microenvironment of gastric liver-like adenocarcinoma

In summary, this study systematically analyzed the molecular characteristics of gastrohepatoid adenocarcinoma at the genome, transcriptome, and microenvironmental levels

Professor Ji Jiafu and Professor Bu Zhaode of Gastrointestinal Surgery of Peking University Cancer Hospital, Peking University Biomedical Frontier Innovation Center (BIOPIC) and Professor Bai Fan from the School of Life Sciences are the co-corresponding authors of the paper

Link to the paper: https://doi.

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