Oncology letters: the combination of soy lecithin and NSAIDs can prevent cancer and have less side effects!

May 31, 2018 / bioin / - when scientists at the University of Texas Health Medical Center (uthealth) applied soy lecithin with a non steroidal anti-inflammatory drug (NSAID), they found that its anticancer activity increased and its side effects decreased The results of this preclinical trial of lecithin are published in the journal oncology letters "The results show the potential application of NSAID in the prevention and treatment of colorectal cancer," said Lenard lichtenberger, Ph.D., Professor of biology and pharmacy at the McGovern School of medicine, uthealth, the lead author of the study The researchers compared the combination of nonsteroidal anti-inflammatory drug indomethacin and soybean lecithin with three other NSAIDs, one of which is aspirin The results showed that the combination of indomethacin and soybean lecithin provided better anti colorectal cancer effect and reduced gastrointestinal bleeding This study is a preclinical trial on a mouse model Colorectal cancer is the third leading cause of cancer deaths in the United States, with 50630 deaths expected this year NSAIDs work by reducing the production of a substance that promotes inflammation, pain and fever They are used to prevent heart disease and reduce arthritis pain, and they can also be used to prevent colorectal cancer "Many cancers are based on inflammation "Anti inflammatory drugs also have potential effects on cancer treatment," he said "However, NSAIDs can also cause problems if you take them for months or years in a row "For non aspirin NSAIDs like indomethacin, the damage to the gut is more severe than gastric ulcer," lichtenberger said This is our latest preclinical trial on soybean lecithin to reduce side effects caused by NSAIDs and have potential anticancer effects "Original source: lichtenberger LM et al Chemoprevention with photodychoine non steroidal anti infectious drugs in vivo and in vitro, oncology letters, 2018