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This article is from the NEJM Journal Watch Prevalence and Description of Persisting Symptoms After COVID-19 Prevalence and Symptoms After COVID-19
Prevalence and Description
Review by Andrew S.
Parsons, MD, MPH
A large observational study in the Netherlands suggests that 1 in 8 people will experience symptoms
after COVID-19.
Although many people develop physical and psychological symptoms after recovering from acute COVID-19, we still know very little
about the extent of the problem.
Studies have relied on follow-up of hospitalized patients, and most patients with COVID-19 are mild and not hospitalized
.
In this prospective observational study, researchers distributed questionnaires to more than 75,000 adults in the Netherlands to assess 23 somatic symptoms
between March 2020 and August 2021.
The researchers matched respondents with COVID-19 (5.
5%) to the age, sex, and time period of the COVID-19 negative control group; Symptom severity was assessed
24 times.
Persistent symptoms (compared to pre-diagnosis and those in the control group) at 90 to 150 days after the diagnosis of COVID-19 include chest pain, dyspnea and pain, myalgia, loss of taste or smell, tingling of the extremities, sensation of hot and cold, and fatigue
.
About 13% of patients have these symptoms attributable to COVID-19, suggesting that 1 in 8 people with COVID-19 have symptoms
after COVID-19.
Comment This large study is the first to describe post-COVID-19 symptoms with correction for pre-infection symptoms
of SARS-CoV-2.
These data are probably the most accurate estimates of prevalence, and the symptoms identified by the investigators can guide our response to the long-term sequelae
of COVID-19.
However, we do not have high-quality data
on persistent symptoms after COVID-19 in vaccinated populations and those infected with new variants.
Commented on the article
.
"NEJM Medical Frontiers" translates several times a week, publishes them on the app and official website, and selects 2-3 articles to be published
on WeChat.
Copyright informationThis article was translated, authored or commissioned
by the Jiahui Medical Research and Education Group (J-Med) and the New England Journal of Medicine (NEJM), which is jointly developed by the New England Journal of Medicine (NEJM).
The full text of the Chinese translation and the charts contained therein are exclusively authorized
by NEJM Group.
If you need to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
cn
.
Unauthorized translation is an infringement and the copyright owner reserves the right to
pursue legal liability.
Prevalence and Description
Review by Andrew S.
Parsons, MD, MPH
A large observational study in the Netherlands suggests that 1 in 8 people will experience symptoms
after COVID-19.
Although many people develop physical and psychological symptoms after recovering from acute COVID-19, we still know very little
about the extent of the problem.
Studies have relied on follow-up of hospitalized patients, and most patients with COVID-19 are mild and not hospitalized
.
In this prospective observational study, researchers distributed questionnaires to more than 75,000 adults in the Netherlands to assess 23 somatic symptoms
between March 2020 and August 2021.
The researchers matched respondents with COVID-19 (5.
5%) to the age, sex, and time period of the COVID-19 negative control group; Symptom severity was assessed
24 times.
Persistent symptoms (compared to pre-diagnosis and those in the control group) at 90 to 150 days after the diagnosis of COVID-19 include chest pain, dyspnea and pain, myalgia, loss of taste or smell, tingling of the extremities, sensation of hot and cold, and fatigue
.
About 13% of patients have these symptoms attributable to COVID-19, suggesting that 1 in 8 people with COVID-19 have symptoms
after COVID-19.
Comment This large study is the first to describe post-COVID-19 symptoms with correction for pre-infection symptoms
of SARS-CoV-2.
These data are probably the most accurate estimates of prevalence, and the symptoms identified by the investigators can guide our response to the long-term sequelae
of COVID-19.
However, we do not have high-quality data
on persistent symptoms after COVID-19 in vaccinated populations and those infected with new variants.
Commented on the article
Ballering AV et al.
Persistence of somatic symptoms after COVID-19 in the Netherlands: An observational cohort study.
Lancet 2022 Aug 6; 400:452.
(https://doi.
org/10.
1016/S0140-6736(22)01214-4)
NEJM Journal Collection
NEJM Journal Watch, published by NEJM Group, invites internationally renowned physicians to review important papers in the field of medicine and help physicians understand and apply the latest advances.
"NEJM Medical Frontiers" translates several times a week, publishes them on the app and official website, and selects 2-3 articles to be published
on WeChat.
Copyright informationThis article was translated, authored or commissioned
by the Jiahui Medical Research and Education Group (J-Med) and the New England Journal of Medicine (NEJM), which is jointly developed by the New England Journal of Medicine (NEJM).
The full text of the Chinese translation and the charts contained therein are exclusively authorized
by NEJM Group.
If you need to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
cn
.
Unauthorized translation is an infringement and the copyright owner reserves the right to
pursue legal liability.
