Operation skill of wet mixed granulator

In recent years, China's pharmaceutical industry has developed rapidly, and the research and development of related equipment has also been highly valued by the pharmaceutical machinery industry At present, the theme of environmental protection has been mentioned The pelletizing equipment manufacturers must grasp the transformation and upgrading of equipment and the improvement of wet process, so as not to be eliminated by the market
Among them, the wet mixed granulator is a kind of solid preparation pharmaceutical equipment with rapid development in recent years In terms of technology, the two-step process of mixing and granulating is combined, which not only saves time but also meets the GMP requirements While reducing cross pollution, it improves the granulation efficiency It is a more quick, better and more economical method, which is popular with users and widely applicable to pharmaceutical, food, chemical industry, etc Industry In the pharmaceutical industry, according to relevant data statistics, wet mixed granulator has accounted for 70% of the current market of several solid preparation granulator Due to the matching use of wet mixed granulator and tablet press, the sales volume of wet mixed granulator in the whole year has a high market share The pharmaceutical industry is developing steadily, and the requirements for wet process are higher and higher Wet granulation technology naturally needs to keep pace with the times Only more environmentally safe granulation methods can be applied in the market At present, the market is unpredictable The wet mixed granulator must grasp the market development trend, maintain its own price, convenient maintenance and other advantages, and at the same time, it should continue to improve its shortcomings, improve its technical strength, so as to make it better applied in the pharmaceutical field It is understood that in foreign countries, the wet mixed granulator has been widely used, the domestic start later According to the industry, some domestic users choose the pharmaceutical equipment of non professional manufacturers When debugging on site, because they don't understand the preparation process and the use skills, they suffer from repeated failures In order to develop solid preparations in China and help users use the purchased wet mixing equipment well, the insiders have published some knowledge for your reference, and the author has carried out the following sorting Generally speaking, the particles made by wet mixed granulation have irregular shape, uniform particle size distribution, perfect structure compared with other traditional granulation processes, strong compressibility, good solubility and moderate moisture permeability At different speeds of granulation, the particle size is 12-100 mesh, and the distribution range can be obtained by selecting different speeds of granulation and agitator (when the speed of granulation is slow, the particle size becomes larger, the speed is gradually accelerated and the particle size is gradually smaller; when the speed of agitator is slow, the particle size is small, the speed is gradually faster and the particle size is gradually increased, and the role of the two is just the same Inverse) In order to find out the technological parameters of the experiment, the speed of agitator and pelletizer can be adjusted by hand That is to say, two kinds of paddle speed are found out through different time changes, and better particle size parameters are obtained According to this, two frequency converters are input for program control, so as to ensure stable and unified quality of batch and batch production.