Osteoarthritis Patients Gospel Scientists use bone stem cells to successfully regenerate joint cartilage.

Osteoarthritis is the most common musculoskeletal disease among people over 60 60 years of age 44.
normal human joint end covered with a layer of joint cartilage, smooth, with a certain thickness, can play an important role in shock reduction, reduce friction and so on.
can cause osteoarthritis due to irreversible reduction of joint cartilage due to aging, obesity, overuse of joints, acute injury, chronic inflammation, etc.
, according to public information, the number of arthritis patients in China has reached 100 million in 2018.
Osteoarthritis treatment usually includes medication, such as analgesics, nonsteroidal anti-inflammatory drugs, intra-joint injection drugs, etc. ;
researchers point out that microfracture surgery can be used to treat damaged cartilage.
surgery stimulates the production of fibrous cartilage by drilling small holes in the surface of the joint, replacing the role of cartilage.
but the fibrous cartilage produced by micro-fractures is not as elastic as natural cartilage and is easier to degrade.
previously, the team had isolated bone stem cells in humans and mice that had the ability to renew themselves and differentiate to produce different types of cells, including cartilage cells.
the new study, researchers analyzed the micro-fracture process in mouse models and found that some bone stem cells were activated during micro-fractures.
Without any intervention, these bone stem cells will spontaneously regenerate into fibrous cartilage, and if they are guided, can they be regenerated into cartilage and stay at that stage?" Cells must go through the cartilage stage before they can form bone.
researchers first used a molecule called bone-forming protein 2 (BMP2) to initiate bone formation after micro-fractures, and then used inhibitors to block the signal of endoskin growth factor (VEGF) in blood vessels, causing bone formation to stop in transit and cell development to stop during the cartilage phase.
, the researchers got cartilage.
Professor Charles Chan, lead researcher on the study, said: "We ended up with cartilage, which has the same type of cells as natural cartilage and is mechanically similar to the usual fibrous cartilage, but similar to natural cartilage" and that "in osteoarthritis mice, this regenerative cartilage allowed the mice to regain their ability to function and significantly reduce pain".
In addition, to see if this method works in humans, the researchers transferred human tissue to mice and conducted experiments that showed that human bone stem cells can guide bone development and stop at the cartilage stage.
next step, the researchers plan to conduct similar experiments on large animals.
Dr Matthew Murphy, lead author of the study, said: "We may start clinical trials with small human joints, which, if effective, could be followed by large joints such as the knee joint.
hope that this new technique will prevent arthritis by promoting the growth of joint cartilage before problems occur, the researchers said.
.