Outbreak of acute hepatitis in unknown children in the United Kingdom and the United States, possibly related to adenovirus type 41, possibly fulminant adenovirus hepatitis

The World Health Organization (WHO) said on April 15 that dozens of children in the UK had acute hepatitis symptoms of unknown origin, some of which were severe enough to require immediate liver transplants.

child

At present, 60 cases are under investigation in the UK.

prevention

At present, the symptoms of British patients are jaundice, diarrhea, vomiting and abdominal pain.

In the United States, since November 2021, the Alabama Department of Public Health (ADPH) has also identified 9 children aged 1 to 6 years with hepatitis, and human adenovirus 41 (HAdV) in the sick children.

Since November 2021, the children have seen providers in different parts of Alabama with symptoms of gastrointestinal disease and varying degrees of liver damage, including liver failure

The Centers for Disease Control and Prevention said in a statement that based on what is currently known, adenovirus may be responsible for these cases, but researchers are still learning more, including ruling out more common causes of hepatitis

Adenovirus 41 is a type of enterovirus

Infect

A domestic literature published last year analyzed the molecular characteristics and evolution of human adenovirus type 41 Fiber gene in children with diarrhea in Beijing from 2010 to 2019.

statistics

However, whether this acute hepatitis is indeed caused by human adenovirus type 41 requires further research

A Mays medical search found that Adenovirus Hepatitis had indeed occurred before, with 12 cases previously reported by Stanford University

43 (48%) were liver transplant recipients, 19 (21%) were bone marrow transplant recipients, 11 (12%) had received chemotherapy, 5 (6%) had severe combined immunodeficiency, and 4 (4%) were HIV-infected, two had heart transplants, and two were kidney transplant recipients

transaminase (AST) (343), alanine transaminase (ALT) (378) and international normalized ratio (INR) (1.

Mays Medicine believes that it is possible that the virus continues to mutate, or some specific mutations appear, causing major changes in its characteristics, thereby causing fulminant adenovirus hepatitis.

At the same time, it also draws our attention that with the continuous changes in the global natural environment, more known and unknown pathogens may appear in the future, and the global prevention and control of infectious diseases, especially the prevention and control of new infectious diseases, has become increasingly challenging

ADPH: Investigations of 9 young children with adenovirus underway; 2 required liver transplants (wbrc.

ADPH: Investigations of 9 young children with adenovirus underway; 2 required liver transplants (wbrc.

Alabama investigates Adenovirus infections in young children - Outbreak News Today

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