Pain, itchy field of the overall topic of thinking design

, itching are negative body feeling, is conducive to the body to avoid sharp objects, high temperature, allergens and other stimuli caused by further injury. The difference is that pain stimulation can cause immediate pain and reflexive avoidance, while itch stimulation can cause long feelings such as the loss of the moon and scratching behavior with no time accuracy.
neurobiology, the activation of pain and itch receptors in the peripheral nervous system can transmit pain and itchy information to the back corner of the spinal cord. Among them, the response of acute pain stimulation mainly depends on the rapid excitation of glutamate neurons in the spinal cord, while itch signaling mainly depends on the release of neuropeptides, such as B-type sodium peptides expressed by itch receptors, neurometrigine B and so on.
Pain
the International Association for pain Research defines pain as "uncomfortable perception and psychological sensation caused by real or potential physical or
tissue
injury". Pain is one of the most common clinical symptoms, often accompanied by reflexive defensive reactions and subsequent licking and stroking behaviors. Pain can be divided into heat pain, mechanical pain, inflammatory pain and nerve pain several categories.
The International Association for pain Research defines neuropathic pain (Neuropathic Pain, N P) as pain caused or caused by primary damage to the nervous system and dysfunction, and in 2011 the official IASP academic journal PAIN clearly defined NeuP (neuropathic pain): pain directly caused by damage to the body's sensory nervous system or disease ." It is a chronic pain characterized by spontaneous pain, pain allergy, abnormal pain, and sensory abnormalities.
chronic pain is a common clinical symptom that lasts long and is difficult to cure and is often referred to as an "edic cancer". At present, at least 100 million people in our country face varying degrees of chronic pain.
the pain transmission path, it is generally believed that the pain receptor received a pain stimulation signal, through the pain transmission path, and finally reached the brain. Edge systems, including the amygdala, are thought to be associated with emotional changes caused by pain, which is a key area of fear formation and expression, and damage to the outer amygdala (basolateral amygdala, BLA) of the substrate reduces pain-induced unpleasantness and avoids behavior without changing the detection threshold for pain stimulation.
itching
itching is a different body sensation from touch, warmness and pain, which can cause conservative scratching behavior in many organisms. Depending on the source of itching, itching is divided into chemical itching and mechanical itching, chemical itching is the itching caused by chemicals, such as mosquito bites, itching caused by pollen allergies, etc.; Chemical itching helps us remove harmful stimuli, and mechanical itching helps us get rid of flying mosquitoes. However, for patients with chronic itching, long-term scratching can cause skin damage, infection, and abnormal pain.
chemical itch signals are transmitted from the outer Nppb neurons to GRP neurons in the spinal cord, to GRPR neurons, and to the brain by projecting neurons. In terms of mechanical itching, we understand the spinal cord NPY inhibitory intermediate neuron gate-controlled mechanical itching.
pain, itching project design
1, chronic pain model (SNI molding, SNL molding, CCI molding, drug molding) and itch model
2, model detection (hot plate experiment, tailing experiment, Von Frey experiment, radiation heat experiment, pain behavior time
statestimal
)
3, drug screening (drug screening ( Analgesic drugs, etc.)
4, molecular mechanism research (with the help of AAV vector, the
gene
over-expression, silence