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    Home > Active Ingredient News > Anesthesia Topics > 【Pain topic】Ropivacaine is used for half the effective dose of pediatric ultrasound-guided median nerve block

    【Pain topic】Ropivacaine is used for half the effective dose of pediatric ultrasound-guided median nerve block

    • Last Update: 2023-01-06
    • Source: Internet
    • Author: User
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    Median effective dose of 0.
    2% ropivacaine for ultrasound-guided median nerve block in young childre.
    0.
    0.
    2% ropivacaine for half of the effective dose


    of pediatric ultrasound-guided median nerve block01

    Introduction:The ESRA and ASRA recommend that ropivacaine is a good choice for ultrasound-guided peripheral nerve block of the upper extremity in children.
    However, there have been no reports on the effective dose of 0.
    2% ropivacaine for this procedure.

    ESRA and ASRA recommend ropivacaine as a good choice
    for ultrasound-guided peripheral nerve blocks in children with upper extremity peripheral nerve blocks.
    However, to date, no effective dose of ropivacaine 0.
    2% has been reported
    for this procedure.



    02

    Objective: To determine the median effective dose (ED50) and the 95% effective dose (ED95) of 0.
    2% ropivacaine for ultrasound-guided lower forearm median nerve block in paediatric patients.

    Objective: To determine the half effective dose (ED50) and 95% effective dose (ED95)
    of ropivacaine 0.
    2% for pediatric ultrasound-guided median nerve block in forearm.



    03

    Methods: Eligible children were American Society of Anesthesiologists (ASA) status I–II scheduled to have elective open surgery for trigger thumb repair.
    Patients were stratified into two age groups: 1- to 3-yearolds and 3- to 6-year-olds.
    The ED50 was determined by Dixon’s up-and-down method.
    The first patient received an ultrasound-guided median nerve block by injection of 2 mL of 0.
    2% ropivacaine.
    Each subsequent patient’s dose was determined by the response of the previous patient, the doses being adjusted in intervals of 0.
    2 mL.
    In addition, the 95% effective dose (ED95) was obtained using a probit regression approach.
    The patients’ general condition, postoperative pain scores, and adverse events were recorded.

    Methods: Eligible children were American Society of Anesthesiologists (ASA) class I-II and were scheduled for selective open surgery for thumb trigger repair
    .
    Patients were divided into two age groups: 1-3 years and 3-6 years
    .
    ED50 is determined
    by Dixon's up-and-down method.
    The first patient received a median nerve block with ultrasound-guided injection of 2 ml of 0.
    2% ropivacaine
    .
    The dose for each subsequent patient is determined by the response of the previous patient, and the dose is adjusted
    at 0.
    2 mL intervals.
    In addition, 95% of the effective dose (ED95) was obtained
    using probabilistic regression methods.
    The patient's general condition, postoperative pain scores, and adverse events
    were recorded.



    04

    Results: A total of 52 children who were scheduled to undergo open surgery for trigger thumb were included in this study: 28 in the 1- to 3-year-olds group and 24 in the 3- to 6-year-olds group.
    The ED50 (95% confidence interval) values were 0.
    9 (0.
    44–1.
    36) mL in 1- to 3-year-olds and 1.
    4 (1.
    14–1.
    66) mL in 3- to 6-year-olds.
    The ED95 (95% confidence interval) values were 1.
    5 (0.
    98–1.
    58) mL in 1- to 3-year-olds and 1.
    7 (1.
    54–1.
    78) mL in 3- to 6-year-olds.
    No adverse events occurred.

    Results: A total of 52 children who were ready for thumb trigger finger opening surgery were enrolled in this study: 28 in the 1-3 year old group and 24 in
    the 3-6 year old group.
    The ED50 (95% confidence interval) value was 0.
    9 (0.
    44–1.
    36) ml for children aged 1 to 3 years and 1.
    4 (1.
    14–1.
    66) ml for children aged 3 to 6 years
    .
    The ED95 (95% confidence interval) value was 1.
    5 (0.
    98–1.
    58) ml for children aged 1 to 3 years and 1.
    7 (1.
    54–1.
    78) ml for children aged 3 to 6 years
    .
    There were no adverse events
    .



    05

    Conclusions: A single dose of ropivacaine was an effective agent for young children requiring ultrasoundguided lower forearm median nerve block in open surgery for trigger thumb.
    The ED50 (95% confidence interval) values were 0.
    9 (0.
    44–1.
    36) mL in 1- to 3-year-olds and 1.
    4 (1.
    14–1.
    66) mL in 3- to 6-year-olds.
    The ED95 (95% confidence interval) values were 1.
    5 (0.
    98–1.
    58) mL in 1- to 3-year-olds and 1.
    7 (1.
    54– 1.
    78) mL in 3- to 6-year-olds.

    Conclusion: A single dose of ropivacaine is an effective drug
    for trigger thumb opening surgery in children requiring ultrasound-guided median nerve block in the forearm.
    The ED50 (95% confidence interval) value was 0.
    9 (0.
    44–1.
    36) ml for children aged 1 to 3 years and 1.
    4 (1.
    14–1.
    66) ml for children aged 3 to 6 years
    .
    The ED95 (95% confidence interval) value was 1.
    5 (0.
    98–1.
    58) ml for children aged 1 to 3 years and 1.
    7 (1.
    54–1.
    78) ml for children aged 3 to 6 years.

















    CONSORT flow diagram of the study02


    Demographic data:03


    3.
    consecutive patients

     

     

    The volume of ropivacaine in patients aged 1–3 years old (n = 28) and patients aged 3–6 years old (n = 24).
    Each solid circle represents a successful nerve block, and each open circle represents a failure nerve block.



    Notes/Bad Head.

    Typesetting/jingle balls


    Median effective dose of 0.
    2% ropivacaine for ultrasound-guided median nerve block in young children.
    pdf


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