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PARP inhibitor Rubraca (rucaparib) in first-line treatment of advanced ovarian cancer significantly prolongs PFS

 Last Update: 2022-04-24
 Source: Internet
 Author: User

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Ovarian cancer is cancer that originates in a woman's ovaries and produces abnormal cells that invade and metastasize to other sites

ovarian cancer

Clovis Oncology, a pharmaceutical company, today announced that its PARP inhibitor Rubraca (rucaparib) significantly extended progression-free survival compared to placebo in first-line maintenance treatment of advanced ovarian, fallopian tube or primary peritoneal cancer (PFS)

Figure 1.

These positive data come from the ATHENA-MONO portion of the Phase III ATHENA study, which is investigating Rubraca in first-line maintenance therapy for ovarian cancer

In an exploratory subgroup of HRD-negative patients, median PFS was 12.

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