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Pax5 promotes PI3K signaling and regulates B cell immunity through down-regulation of PTEN

 Last Update: 2021-07-30
 Source: Internet
 Author: User

Pax5 regulates mature B cells

B cells are a key part of the adaptive immune response, so a better understanding of their development and maturity is crucial
.

B cell development is controlled by the transcription factor Pax5, but whether Pax5 regulates B cell maturation is unclear

Summary

The transcription factor Pax5 controls the development of B cells, but its role in mature B cells is still a mystery
.

Here, we demonstrated that the absence of Pax5 in the conditional mutagenesis of peripheral blood B lymphocytes resulted in a strong reduction of B-1a, marginal zone (MZ), germinal center (GC) B cells and plasma cells

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