Pay attention to the development of tablets and improve the quality of tablets

It is reported that tablet is developed on the basis of pill use It was created and used in 1840's by the end of 19th century, with the appearance and continuous improvement of tablet pressing machine, the production and application of tablet have developed rapidly In recent years, China has attached great importance to the development of tablet production technology, tablet excipients and production equipment, and the collection and arrangement of medical education network has done a lot of work to improve the quality of tablets, making great progress Tablet production technology and related mechanical equipment also have great development, such as all kinds of new granulation technology and equipment, direct powder tablet pressing technology and corresponding auxiliary materials, high-speed automatic tablet pressing machine, fully automatic program-controlled coating equipment, new packaging equipment and materials such as aluminum plastic packaging, etc There are also great developments in the auxiliary materials for tablets, such as adhesives, disintegrating agents, various types of coating materials suitable for various purposes, etc In recent years, many kinds of compound excipients have been developed abroad, such as compound excipients for direct compression and coating The collection and arrangement of medical education network has played a great role in improving the production conditions and quality of tablets Due to the development of new technology, tablet as a dosage form has never been so eye-catching Through adjusting the color, taste and other components of auxiliary materials, pharmaceutical factories produce various tablets, competing products But on the whole, compared with other main dosage forms, the research on tablets in China is relatively lagging behind, the theoretical level and technical level, so that the quality of tablets needs to be improved The research and production of traditional Chinese medicine tablets began only in the 1950s With the comprehensive research of traditional Chinese medicine chemistry, pharmacology, preparation and clinical aspects, the variety and quantity of traditional Chinese medicine tablets are increasing, the technology is improving, and the quality of tablets is improving In addition to the general pressed tablets, sugar coated tablets, there are also microcapsule tablets, buccal tablets, external tablets and effervescent tablets In the aspect of tablet production technology, a set of technological conditions suitable for the production of traditional Chinese medicine tablet has been gradually explored, such as the preparation of tablet containing fat oil and volatile oil, how to improve the hardness of traditional Chinese medicine tablet, how to improve the disintegration, how to coat tablet and so on, so as to improve the quality continuously In addition, the research on dissolution rate and bioavailability of drugs in traditional Chinese medicine tablets has been gradually carried out In short, at present, tablet has become one of the types with many varieties, large output, wide use, convenient use, storage and transportation, and quality stabilizer Tablet accounts for more than 1 / 3 of the preparations in Pharmacopoeia of China and many other countries, which shows its wide application 　　 With the development of pharmacokinetics, medical polymer materials, and the improvement of production process, various dosage forms of chemicals have made great progress At present, people have paid attention to the research and development of new tablets In addition, with the large-scale application of new tablets, the toxicity of new tablets in clinical has also attracted the attention of relevant researchers and carried out research on them 。 In this regard, zyzhan small editor thinks that it is the research focus of tablets in China to improve scientific research institutions, improve innovation system, vigorously cultivate innovative talents, and research new drugs with independent property rights