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Hepatoid adenocarcinoma of the stomach (HAS) is a very rare but highly malignant gastric tumor in clinical practice
Recently, the team of Professor Ji Jiafu of Gastrointestinal Surgery of Peking University Cancer Hospital, the team of Peking University Biomedical Frontier Innovation Center (BIOPIC) and Professor Bai Fan of the School of Life Sciences published an online publication titled " Genomicand transcriptomic profiling of hepatoid adenocarcinoma of " in Oncogene .
Figure 1: Research strategy for gastric liver-like adenocarcinoma
Researchers performed multi-omics joint analysis on gastric hepatoid adenocarcinoma, comprehensively applied exon sequencing, transcriptome sequencing and single-cell transcriptome sequencing methods, and completed the extracorporeal analysis of 58 tumor tissues in 55 patients with gastrohepatoid adenocarcinoma.
Figure 2: Monoclonal origin characteristics of gastric liver-like adenocarcinoma
In order to further explore the gene expression characteristics of gastric liver-like adenocarcinoma, the researchers systematically compared the expression profiles of gastric liver-like adenocarcinoma with gastric adenocarcinoma and hepatocellular carcinoma
Figure 3: Gene expression characteristics of gastric liver-like adenocarcinoma
Finally, using single-cell transcriptome research methods, the researchers conducted a preliminary exploration of the tumor microenvironment of gastric-hepatoid adenocarcinoma and discovered the complex cell differentiation characteristics of gastric-hepatoid adenocarcinoma (Figure 4)
Figure 4: The complex cell differentiation characteristics and tumor microenvironment of gastric liver-like adenocarcinoma
In summary, this study systematically analyzed the molecular characteristics of gastrohepatoid adenocarcinoma at the genome, transcriptome, and microenvironmental levels
Professor Ji Jiafu and Professor Bu Zhaode of Gastrointestinal Surgery of Peking University Cancer Hospital, Peking University Biomedical Frontier Innovation Center (BIOPIC) and Professor Bai Fan from the School of Life Sciences are the co-corresponding authors of the paper
Reference:
Ishikura H, Fukasawa Y, Ogasawara K, Natori T, Tsukada Y, Aizawa M.
Su JS, Chen YT, Wang RC, Wu CY, Lee SW, Lee TY.
Liu X, Cheng Y, Sheng W, Lu H, Xu X, Xu Y et al.