Peptic ulcer gastric fluid sIgA with Helicobacter pyridobacteria infection

NetworkPeptic ulcer gastric fluid sIgA and Helicobacter pyridosis infection 1 object and method 1.1 object all cases were examined and pathologically confirmed by the gastroscopy room of our hospital, of which 31 cases of gastric ulcer (GU), an average of 39 years old; In 30 cases in the control group, with an average age of 32.7 years, gastroscopic biopsies confirmed that there were no significant abnormalities. 1.2 Methodendoscope with plastic tube through biopsy holes, extraction of gastric fluid 5 ml to 10 ml, gastric fluid pH 6 or less with sodium bicarbonate powder to 6-8, and then ice melt, centrifugation, the above liquid preparation test. Gastric fluid sIgA determination using radioimmune method, the box provided by the Chinese Academy of Atomic Energy Sciences. Gastric sinus mucous membrane Helicobacter pyridobacteria (Hp) detection, the use of fast urea enzyme semi-quantitative method, the medicine box provided by Fujian Sanqiang company.2 resultsfrom Table 1, GU, DU stomach IgA is lower than normal, and has
statistical
significance. From Table 2, it can be seen that the sIgA hydrological level of the active ulcer disease group is lower than that of the in<0.01). According to the level of peptic ulcer gastric fluid sIgA is low, medium and high sIgA three groups, low sIgA group HP (+) accounted for 66.7%, middle sIgA group HP (++) accounted for 46.7%, high sIgA group HP (s) 16.7%, sIgA level is lower, the higher the hp infection group (see Table 3).Table 1 Peptic ulcer gastric fluid sIgA changes (x±s, g/L)
group n gastric fluid sIgA control 30 0.051±0.081 GU 31 0.022±0.091b DU 35 0.0148±0.011b
bP<0.01, vs control group.Table 2 Peptic ulcer activity compared to in activity group sIgA (g/L)
group number of gastric fluid sIgA active group 20 0.0085±0.0034b GU in activity group 11 0.0460± 0.0170b Activity Group 23 0.0063±0.0010 DU In activity Group 12 0.0310±0.0080b
bP<0.01, vs Group.Table 3 Peptic ulcer sIgA and HP infection level relationship
sIgA cases in the low group <0.008 21 3 (14%) 4(19%) 14(67%) Group ≤0.020 15 2 (13%) 6(40%) 7(47%) High group >0.020 12 8 (67%) 2(17%) 2 (17%)
P<0.05, X -215.23 3 Discuss the eganisms ofpeptic ulcers more, in recent years, most scholars believe that hp infection is closely related, there are foreign scholars believe that may be related to immune disorders, we have conducted research on peptic ulcers systemic and local fluids and cellular immunity disorders. The systemic immune response is different from the local immune response, and the local immune function of mucous membranes can better explain the relationship with ulcer disease. SIgA plays the most important role in the immune function of local mucous membranes. There are few domestic reports on the level of peptic ulcer gastric fluid sIgA and its relationship to HP infection. Our results showed that gastric fluid sIgA levels were lower in patients with gastric heteostrides than in the normal control group, with the most significant reduction in heteental ulcers. The level of gastric fluid sIgA for gastric ulcers was lower than that of in activity. Although hp is currently thought to be closely related to peptic ulcers, there is no satisfactory explanation as to why peptic ulcers have a high hp infection rate. We observed that the lower the level of sIgA in patients with peptic ulcers, the heavier the hp infection. SIgA is the most important protective
antibody
the gut, it has the effect of inhibiting bacterial adhesion, neutralization of toxins, soluble bacteria. The decrease in SIgA indicates that local mucous membranes are less resistant to infection and may be more susceptible to bacteria. This suggests that stomach heteoscopic ulcers, especially those with two-fingered intestines, may be one of the more serious causes of HP infection. The reasons for SIgA's decrease need to be further explored.Chengyong Zhu Ju Department of Internal Health , Shandong Provincial Hospital (Jinan 250021)