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Pharmaceutical Grade Cross-Linked Povidone Pvpp Disintegration Agent Filler Pharmaceutical Grade Crosslinked Povidone Pvpp Disintegrant Filler Crossvidone Jiaolian Juweitong Crosspovidone This product is an insoluble water-soluble homopolymer
synthesized from N-ethylene-2-pyrrolidone synthesis.
The molecular formula is (C6H9NO)n, where n represents the average number of
1-vinyl-2-pyrrolidinone links.
According to the anhydrous calculation, the nitrogen content (N) should be 11.
0% to 12.
8%.
【Properties】This product is white or off-white powder
.
This product is insoluble
in water and ethanol.
【Identification】 (1) Take 1g of this product, add 10ml of water to shake to disperse into a suspension, add 0.
1ml of iodine test solution, shake for 30 seconds, add starch indicator solution 1ml, shake, should be no blue production
.
(2) The infrared light absorption pattern of this product should be consistent with the pattern of the control product (General Principle 0402
).
【Inspection】 PH Take 1.
0g of this product, add 100ml of water and stir to make a uniform suspension, determine according to law (general 0631), pH value should be 5.
0 ~ 8.
0
.
Soluble substances in water Take 25.
0g of this product, put it in a beaker, add 200ml of water, stir for 1 hour, quantitatively transfer it to a 250ml measuring bottle with water, dilute it with water to a scale, shake well, let stand (generally not more than 24 hours), take the upper layer of solution, centrifuge for 30 minutes (3500 revolutions per minute), take the supernatant filtered through a 0.
45μm filter membrane, take a precise amount of 50ml of filtrate, place it in a beaker that has been dried at 105 ° C for 3 hours and weighed, evaporate to dry, dry at 105 ° C for 3 hours, and the residual residue shall not exceed 50mg (1.
0).
%)
。
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