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    Home > Active Ingredient News > Drugs Articles > Pharmaceutical grade mannitol 25kg Jinyang can be used in excipients

    Pharmaceutical grade mannitol 25kg Jinyang can be used in excipients

    • Last Update: 2022-08-20
    • Source: Internet
    • Author: User
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    Pharmaceutical grade mannitol 25kg Jinyang can be used in excipients Mannitol mannitol is D-mannitol
    .

    Calculated according to the dry product, the content of C6H14O6 should be 98.
    0% to 102.
    0%
    .

    Mannitol is white crystal or crystalline powder; odorless
    .

    Mannitol is readily soluble in water and almost insoluble or insoluble in ethanol
    .

    Melting point The melting point of mannitol (general rule 0612) is 166~170℃
    .

    Take about 1g of this product for specific rotation, accurately weigh it, put it in a 100ml measuring bottle, add 40ml of ammonium molybdate solution (1→10), then add 20ml of 0.
    5mol/L sulfuric acid solution, dilute with water to the mark, shake well, Measured according to the law at 25°C (General Rule 0621), the specific rotation is +137° to +145°
    .

    [Identification] (1) Take 1ml of the saturated aqueous solution of this product, add 0.
    5ml of ferric chloride test solution and 0.
    5ml of sodium hydroxide test solution, that is, a brownish-yellow precipitate will be formed, which will not disappear when shaken; add excess sodium hydroxide to test liquid, which dissolves into a brown solution
    .

      (2) The infrared absorption spectrum of mannitol should be consistent with the control spectrum (spectrum set 1238)
    .

    Mannitol is pure in the form of powder or crystal in warm environment.
    Mannitol does not have the characteristics of hygroscopicity; however, it will cause the phenomenon of powder cohesion
    .

    Usually it can be used as a filler for tablets or capsules, an adjuvant for freeze-dried preparations; and a food additive
    .

    In terms of food, the product has low water absorption in sugar and sugar alcohol, and has a refreshing sweetness.
    It is used for anti-sticking of maltose, chewing gum, rice cakes and other foods, and as anti-sticking powder for general pastries
    .

    Dibromomannitol can be prepared by reaction with hydrobromic acid
    .

    As an excipient for tablets, mannitol has no hygroscopicity, fast drying, good chemical stability, and has the characteristics of refreshing taste and good granulation
    .

    Mannitol Mannitol is more widely used in the manufacture of chewable tablets such as hangover medicine and oral cooling agent because of its heat absorption, sweet taste and oral comfort when dissolved.
    Its granular form is specially used as an excipient for direct compression
    .

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