Pharmaceutical grade sodium benzoate chemical properties use

Pharmaceutical grade sodium benzoate Sodium benzoate Chemical Properties Benzoic acid and sodium benzoate are widely used as preservatives in food processing and preservation, and are used
in some foods.
Because benzoic acid can play a role in the free state in food, it has a good
effect in strong acid food.
Benzoic acid is generally used in carbonated drinks, soy sauce, sauces, preserves and fruit and vegetable drinks, and benzoic acid can be used with p-hydroxybenzoates in soy sauce and beverages to increase efficiency
.
Benzoic acid and sodium benzoate are often used to preserve highly acidic fruits, jams, beverage syrups and other acidic foods, which can be sterilized at low temperatures and play a synergistic effect [2].

Benzoic acid and sodium benzoate are generally limited to foods
with high protein content.
Sodium benzoate has the same effect on microorganisms as benzoic acid, but because it is a sodium salt, if you want to achieve the same bactericidal effect as benzoic acid, the required amount of addition is 1.
2 times that of benzoic acid [Identification] (1) take about 0.
5g of this product, dissolve it in 10ml of water, and the solution shows the reaction of sodium salt identification (1) and the identification reaction of benzoate (General rule 0301).

(2) In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent
with the retention time of the main peak of the reference solution.
(3) The infrared light absorption spectrum of this product should be consistent
with the control spectrum (spectral set 234 figure).
【Check】pH take 1.
0g of this product, dissolve it with 20ml of water, add 2 drops of phenolphthalein indicator solution; if it is light red, add sulfuric acid titration solution (0.
05mol/L) 0.
25ml, light red color should disappear; if colorless, add sodium hydroxide titration solution (0.
1mol/L) 0.
25ml, should appear light red
.
The clarity and color of the solution take 1.
0g of this product, add 10ml of water to dissolve, check according to law (General 0901 and General 0902), the solution should be clear and colorless
.
chloride take 0.
20g of this product, add water to dissolve it into 25ml, add 10ml of dilute nitric acid, shake well, filter after the precipitation is complete, wash the filter with a small amount of water, combine the washing solution and the filtrate, check according to law (General 0801) and compare with the control solution made of 6.
0ml of standard sodium chloride solution, not more concentrated (0.
03%)
。 sulfate take 0.
40g of this product, dissolve it with 40ml of water, slowly add 4ml of dilute hydrochloric acid while stirring, let stand for 5 minutes, filter, take 20ml of the continued filtrate and put it in a 50ml Knott's colorimetric tube, add water to the scale, shake well, as a test solution; measure 2.
4ml of standard potassium sulfate solution, put it in a 50ml Knott's colorimetric tube, add 2ml of dilute hydrochloric acid, add water to the scale, shake well, as a control solution
.
Add 5ml of barium chloride solution to each of the two solutions, shake well, and the turbidity of the test solution should be shallower than that of the control solution (0.
12%)
.
loss on drying take this product, dry to constant weight at 105 °C, and the weight loss shall not exceed 1.
5% (General rule 0831).

heavy metals take 2.
0g of this product, add 45ml of water, stir constantly, add 5ml of dilute hydrochloric acid dropwise, filter, separate 25ml of filtrate, check according to law (General Principles 0821 first law), containing heavy metals shall not exceed 10
parts per million 。 Arsenic salt take 2.
5g of anhydrous sodium carbonate, spread it on the bottom and around the crucible, then take 1.
0g of this product, put it on anhydrous sodium carbonate, moisten with a small amount of water, after drying, first burn with low fire to carbonize, and then burn at 500~600 °C to completely ash, cool, add 5ml of hydrochloric acid and 23ml of water to dissolve, check according to law (General Principles 0822 First Law), should comply with the provisions (0.
0002%)
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