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    Home > Medical News > Latest Medical News > Pharmacopoeia: Guidelines for the determination of powder flowability published

    Pharmacopoeia: Guidelines for the determination of powder flowability published

    • Last Update: 2022-12-30
    • Source: Internet
    • Author: User
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    Source: Pharmacopoeia Editor: Wang Xinglai2004

      

    On December 19, 2022, the National Pharmacopoeia Commission issued the Guidelines for the Determination of Powder Fluidity, and the publicity period is 3 months
    from the date of publication.



    Key Highlights:

    There are several
    ways to determine the angle of rest.
    The most common method for determining static rest angle can be classified based on the following two important experimental variables:

    • The height of the powder through the "funnel" is fixed relative to the chassis, or its height can change
      with the formation of the cone.
    • The diameter of the chassis forming the cone is fixed, or the diameter of the powder cone can change
      with the formation of the cone.
    The angle of rest is not intrinsic to powders, and the results of the determination depend largely on the method
    of forming powder cones.
    The main influencing factors include:
    • The tip of the powder cone is deformed
      by the impact of the powder coming out from the upper part.
      By carefully constructing the powder cone, the deformation of the powder cone due to impact can be minimized
    • The properties that form a powder-cone chassis affect the angle of rest
      .
      It is recommended to form a powder cone on a "common chassis", which can be achieved
      by forming a powder cone on a layer of powder.
      This can be achieved
      by using a fixed diameter chassis with a protruding outer edge that retains a layer of powder on which a powder cone is formed.
    • When measuring the fluidity of powder, the state of the tested sample will affect the measurement result, and for samples with strong hygroscopicity, small particle size and easy agglomeration, the ambient humidity may affect
      the measurement result when the ambient humidity is too high.
      Therefore, in the sample test, the sample status needs to be observed, the ambient humidity is detected and explained
      in the test report.

    Original text of the announcement

    In order to ensure the scientificity, rationality and applicability of the standard, the proposed standard is now publicized to solicit opinions from all walks of life, the specific content is as follows:

    Publication of Draft Standards for Guidelines for the Determination of Powder Flow - National Pharmacopoeia Commission (chp.
    org.
    cn)


    The publicity period is 3 months
    from the date of publication.
    Please carefully review, if there is any objection, please submit feedback in time, with relevant instructions, experimental data and contact information
    .
    The relevant letter must be stamped with an official seal, and the personal letter must be signed by the person in person, and the electronic version should be sent to the designated email address
    .

    Contact: Chen Lei, Kang Xiaobo

    Tel: 010-67079566, 67079620

    Email: 475@chp.
    org.
    cn

    Mailing address: Office of the National Pharmacopoeia Commission, Building 11, Fahuanan Li, Dongcheng District, Beijing

    Zip code: 100061


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