Phosphatidylsine: Precision sniping of cognitive problems in the brain

cognitive ability marketAs the spirit of all things, man is far superior to other animals, that is, has the most developed mind in the biological world. From the ancient times human learning to use and produce tools, to the four civilizations of the ancient culture of the splendid, to the changes of the modern industrial revolution, and now we are experiencing the changes in the information age, the development of human civilization behind the external embodiment of human wisdom, and these are based on the complex human brain activities.basic physical functions, to memory, language, reactions, sense of space-time, thinking and so on, brain activity supports the normal development of daily work and learning.For children and adolescents, according to the Swedish cognitive expert
Jean Piaget
well-known cognitive development stage theory, adolescents are in the process of cognitive ability formation until the age of
16
, but the objective situation is that the heavy academic burden and the pressure of further education, so that children and adolescents at this stage of life may be the heaviest brain load in life., like many other body parts, brain functions age as humans age. So at what age does a person's cognitive abilities begin to age?
Timothy Salthouse
is director of the Cognitive and Aging Laboratory at the University of Virginia and has served several times as a member of the
NIH
Scientific Review Committee, a member of the Cognitive Aging Summit Program, and has participated in a number of National Institutes of Health's cognitive assessment programs.
Timothy
published his research on cognitive
aging in

in
2009, and as a result, cognitive ability began to deteriorate around the age of
30
. This degradation will continue into old age.older, another, more serious cognitive problem, dementia, will also be highlighted.

2014, the World Health Organization
47.
million people over the age of
60,
have dementia, of whom more than
58%
are from low- and middle-income countries.
WHO
predicts that
7.
million new people are living with the disease each year, and that the number of people aged
60 and over with dementia will reach
75.

million by
2030
. In China, the number of people aged

and over now accounts for
10.01%
of the total population, and with a large population base, china's cognitive health problems will continue to rise.History and Discovery of PS
Scientific research is a typical iterative process of repeated feedback, constantly generating new discoveries based on old research, correcting the past with new results and exploring the unknown again, in which it gradually approaches the truth of the unknown. After years of slow replacement of cognitive function products, the cognitive demand market urgently needs a better raw material, safer, more accurate effects, more specific brain function to meet the growing consumer concerns and demand for cognitive function products, while driving the change of cognitive products market pattern. At present, phosphatidylserine (
Phosphatidylserine
,
PS
) is the most powerful to carry the industry's expectations of raw materials.

1940s,
Jordi Folch Pi
, a young neurochemist at Harvard University, first isolated the
PS
. Since then, the
PS
in the brain has been extensively studied.fact,
PS
is the basic component of life.
PS
is one of the cell membranes, and all life on Earth has cell membranes. For humans, the human brain is
most
PS-rich organ, accounting for about 15% of all phospholipids
the brain
brain. Compared to other phospholipids,
PS
is the only type of negatively charged membrane phospholipid, and this particular property determines the important function of
PS
: the formation of specific anchoring points on the endometrial membrane of nerve cells. These anchor points are necessary for nerve cells to perform normal functions. What if there is no
PS
in the human body? There have been studies by scientists that have used gene knock-out techniques to prevent embryos in mice from synthesized
PS
, with the end resulting in embryo death, suggesting that
PS
is an important substance necessary for human growth and development. In nerve cells,
PS
is involved in regulating a variety of cell path pathps, of which the more important are the
PI3K/Akt
path,
Ras/Raf
path, and the protein kinase
C
path, through which
PS
affects the survival, proliferation, differentiation and apoptosis of nerve cells.addition,
PS
also promotes the release of neurotransmitter between nerve cell synapses, thus speeding up intercellular transduction of nerve signals.For the average consumer, it may be difficult to understand the importance of
PS
for the signaling path of nerve cells, but most of them have experienced the consequences of the lack of
PS
: Dr.
Kim Hee Yong
, director of the Institute on Alcohol Abuse and Alcohol Addiction at the U.S. Department of Health, points out that the synthesis and functioning of
PS
is greatly inhibited by alcohol in the body. For those who have had the experience of "drinking shrapder", the lack of
PS
caused by a mere meal can cause memory loss, which shows the importance of
PS
to memory function.

Symposium on New Advances in Alzheimer's Disease, hosted by the China Committee of the International Alzheimer's Association and the Beijing Alzheimer's Association, the lead expert from the Alzheimer's Association of Israel,
Itay Shafat
Dr. said phosphate is one of the most important phospholipids that can directly act on the brain's cell membranes and is effective in improving cognitive function in the brain over the long term, as well as enhancing the efficiency of neurotransmitters that transmit signals of cognitive function in the brain, improving memory, improving cognitive impairment in old age and preventing Alzheimer's disease. the current mainstream
PS
research project concluded that
PS
is beneficial for children with ADHD, Alzheimer's disease, memory function, cognitive function, and emotional soothing. Some studies focusing on other areas have
PS
even improved motor performance. Where does
source of PS data, lack supplements,
PS
come from? Because of its ability to survive,
PS
is an ingredient that can be synthesized on its own, and we naturally consume
PS
from food every day, and animal guts are a richer
PS
food. However, due to factors such as individual age and enzyme system activity in the body, the
synthesis
PS system is affected. And because of the popularity of the concept of healthy eating in today's world, fewer and fewer people like to eat the guts, and although the visceral
PS
content is high, but also contains a lot of unhealthy cholesterol. Fda
based on available information, the average person's daily intake of
PS
through a normal diet is currently about
130 mg less than it was in the
1980
s
And scientists have confirmed through clinical trials that changes
PS
PS intake can have an impact on mental activity. By supplementing
PS
with an out-of-diet diet, the goal of increasing brain activity was achieved, and the subjects' cognitive performance was improved in just a few months, compared to
DHA
, which had no improvement in
5
years. now,
PS
is safe and adequate to supplement
100mg
daily with
FDA


permission. At present, the common
DHA
specifications on the market in addition to health care products per take specifications reached
100mg
per day, generally for each unit of
10 to 20mg
specifications, multiple times a day to supplement, and some products will be supplemented by
DHA
, Ginkgo and other elements. PS
Regulation and Applications PS
is the only U.S.
FDA
certified ingredient worldwide that claims cognitive efficacy. It was also
the
GRAS
by
FDA
in
2007. the United States is the world's largest health care products market, health care products categories, brands, market segments, regulatory mechanisms have been fully developed. There are now dozens of
PS
products listed in the U.S., with the larger
Now Foods
,
Swanson
,
Doctor
'
Best
,
Jarrow Formulas
,
Integrative Therapeutics
,
GNC
,
Solgar
,
Puritan
'
s Pride
, etc., the vast majority are
100mg
softgels for daily supplements
PS
. It's worth noting that more than
60%
of these brands use
Sharp
, produced by Israeli
PS
maker
Enzymotec
and NASDAQ
ENZY
PS
as a raw material because Anseco is the world's largest
PS
manufacturer and an applicant for
GRAS
certification. Anseko has a licensing agreement with most U.S. health care manufacturers that allows them to print
Sharp
.
PS
brand logo to increase product recognition. of the
20
U.S. direct selling companies announced by the American Direct Marketing Association
DSA
,
9,
companies develop and sell brain-health products in categories of
19
, the most used of which are
DHA
and Ginkgo, containing
DHA
or Ginkgo categories up to

species, the application of
PS
only

Unforgettables

(one supplement per day
100mgPS
,
60mgDHA
,
60mg EPA
, supplemented by ginkgo extract, blueberry extract and choline), and Yusana (
SANA
)
Ginkgo-PS
(daily supplement
25mg
Ginkgo biloba extract and
125mg
phospholipids containing
PS
). day