Physiological regulation mechanism of "dawn phenomenon" in diabetic patients

China News Online, March 25th (Chen Jinghongxuan) Among diabetic patients, a "dawn phenomenon" occurs in some patients, which means that such patients may have abnormal rhythms of insulin sensitivity.

The reporter learned on the 25th that medical experts from China and the United States worked together to reveal the mechanism by which the REV-ERB gene controls insulin to inhibit the circadian rhythm of liver gluconeogenesis.

Related research papers completed by Ding Guolian's group at Fudan University's Obstetrics and Gynecology Hospital/Reproductive and Development Research Institute, Sun Zheng's group at Baylor College of Medicine, and Chen Li's group at Shandong University Qilu Hospital were published online on the 25th in Nature.

It is understood that in clinical practice, some diabetic patients can control their blood sugar level at night or during most of the day, but they have high blood sugar at dawn, especially after breakfast.

In clinical studies, researchers used continuous dynamic blood glucose monitoring to divide patients with type 2 diabetes into a dawn phenomenon group and a non-dawn phenomenon group.

According to reports, the study reveals the regulation mechanism of insulin sensitivity rhythm in glucose metabolism, not only explaining physiological phenomena, but also providing mechanism explanations and treatment suggestions for the "dawn phenomenon" that plagues diabetic patients.