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<> The "clear" >
plasma protein is the most important solid component in the plasma, the content is 60 to 80g/L, plasmaprotein a variety of functions. The plasma protein can be divided into different kinds by different separation methods. Initially, the plasma protein was divided into albumin and globulin, and later it was subdivided into albumin, globulin, euglobulin and fibrin. The film electrophoresis method of acetic fiber can be divided into 5 zones, such as albumin, alpha1 globulin, alpha globulin, β-globulin and γ-globulin, while the electrophoresis method with high resolution polyacrylamide coagulation can be divided into more than 30 zones. Two-way electrophoresis combined with isoelectration focus electrophoresis and polyacrylamide electrophoresis has a higher resolution and can divide plasma protein into more than one hundred species. At present, the clinical use of simple and fast acetate fiber film electrophoresis method, the type of plasma protein obtained and the normal content can be seen in Table 10-1.
Table 10-1 plasma protein type, production site, main function and normal content
Table 10-2 plasma protein components name, concentration and biological activity
| name> | ||||
| the | concentration (mg/100 ml) in normal plasma | biological activity | ||
| albumin: | ||||
| pre-albumin | PA | 28-35 | in combination with thyroxine | |
| . Albumin | AIb | 4,200±700 | maintains plasma collosine permeation pressure, transportation, nutrition | |
| alpha1 globulin: | ||||
| α lipoprotein (HDL) | HDL | 217-270 | phosphate, triglycerides, cholesterol, liposolysol vitamin transport | |
| alpha1 acidic glycoprotein | alpha1AGP | 75-100 | also known as whey-like mucous protein, the initial active substance of infection, inhibits progesterone | |
| a href<> | alpha1AT | 210-500 | . Anti-tryprotein and protease | |
| Salpamine protein I. | in combination with vitamin B12 | |||
| transport cortisol protein | TSC | 5-7 | transport cortisol | |
| methyl fetal protein | AFP | 0.5-2.0×10-3 | ? | |
| alpha2 neural glycogen | C1s I | 24±10 | inhibits the first component of the supplement C1s | |
| (C1s esterase inhibition) inhibitors | thyroxine binding globulin | |||
| TBG | 1-2 | and thyroxine (T4) binding | ||
| alpha2HS glycoprotein | alpha2HS | ? | .activated when the inflammation occurs | |
| copper orchid | CP | 27-63 | has oxidase activity, binding with copper, participating in copper metabolism, acute time reactions | |
| coagulation enzymes | 5-10 | participating in coagulation | ||
| alpha 2 globulin | alpha2M | 200±66 0 | inhibits fiber lysase and trypsin, active growth yarn and insulin, can also be combined with other low molecular substances, acute anti-inverse | |
| cholinesterase | ChE | 1±0.2 | hydrolyzed acetylcholine | |
| thyrotin binding globin) | Hp | .100 (30-190) | and Hb binding | |
| vascular tensionogen | causes blood vessels to constrict and raise high blood pressure | promotes aldehyde solids | ||
| redocycell progenesin | ketone secretion promotes RBC production | |||
| alpha2 lipoprotein (VLDL | alpha2Lp | 28-71 (with age sex) Different) | transport lipids (mainly triglycerides), fat-soluble vitamins and > | |
plasma proteins are diverse, and various plasma proteins have their unique functions, except by separation method. Functional classification is also used. Can be divided into the following 8 categories: (1) clotting system proteins, including 12 types of clotting solids (except Ca2 plus). (2) Fiber-soluble system proteins, including fibre-lysase, fiber-lysase, activators and inhibitors. (3) Supplemental system protein. (4) Immunoglobulin. (5) Lipoprotein. (6) Plasma protease inhibitors, including enzyme activation inhibitors, blood coagulation inhibitors, fibre lysase inhibitors, peptide release inhibitors, endogenous proteases and other protease inhibitors. (7) Carrier protein. (8) Unknown function of plasma proteins.
< p class> "tt1" plasma protein has the following common characteristics:1. The vast majority of plasma protein is synthesized by the liver. In γ globulin is synthesized by plasma cells, and endoblasts are synthesized into a small amount of plasma protein.
< p class " "tt1" > 2. Plasma protein is a secretion protein. Synthesis on polyurucleosomes (pllyribosomes) combined with the meat mesh, before secretion into the plasma undergoes the process of shear signal peptides, glycosylation, phosphorylation to become mature proteins. < p class .tt1> 3. Plasma proteins are almost always glycoproteins, containing N-or-O-connected oligosaccharin chains. Only a few sugar-free proteins, such as albumin, retinol binding protein and C-reactive protein. The sugar chain can participate in the formation of the three-stage structure of plasma protein molecules and has many functions. < p class " "tt1" > 4. All kinds of plasma proteins have their characteristic circulating half-life. < p class "tt1" > 5. Many plasma protein polymorphisms. Polymorphism refers to more than two types of expressions in the same genus, which occur at least 1% frequency. The most typical is the ABO blood type substance. In addition, alpha1 antitrypsin, binding globin, ferrotransertic protein, plasma copper blue protein, etc. all show polymorphism. The study of plasma protein polymorphism is of great significance to genetics and the < of a href" > ofof clinical medicine.6. Some plasma protein levels increase when acute inflammation or"> tissue" is damaged. These plasma proteins are called acute phase proteins. Includes C-reactive protein (CRP), alpha1 antitrypsin, alpha2 acidity.
