PLOS MED: Age at Menarche?

Reproductive factors in women are associated with dementia risk; however, these findings remain inconclusive

Reproductive factors in women are associated with dementia risk; however, these findings remain inconclusive

A total of 273,240 women and 228,957 men without endemic dementia from the UK Biobank were included in the analysis

During a median follow-up of 11.

During a median follow-up of 11.

The risk of dementia was 15% lower in those who had been pregnant compared with those who had never been pregnant (HR = 0.

Dementia risk associated with number of children in women and men

Dementia risk associated with number of children in women and men

The U-shaped relationship between the number of children and dementia risk was similar for both sexes

The U-shaped relationship between the number of children and dementia risk was similar for both sexes

In this study, reproductive events associated with shorter cumulative exposure to endogenous estrogens in women were associated with higher dementia risk, and there were similar associations between the number of children and dementia risk in women and men

references:

references:

Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants.

Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants.
https://doi.
org/10.
1371/journal.
pmed.
1003955 Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants.


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