PLoS: Research shows that after severe COVID-19, the durability of immune memory decreases

A new study shows that among university hospital patients who have recovered from mild cases of COVID-19, anti-infection B cells have better memory of coronavirus spike protein than patients who have recovered from severe COVID-19 patients

Dr.

The focus of this research is on memory B cells that respond to the SARS-CoV-2 spike protein

However, the authors wrote that samples from eight individuals who recovered from a milder disease showed increased expression of markers associated with persistent B-cell memory compared to individuals who recovered from a severe disease

The authors noticed that T-bet was positive, and spike-specific B cells almost disappeared from the blood sample 5 months after the onset of symptoms

Non-severe cases do not require supplemental oxygen or invasive ventilation, and severe cases require invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO)

Study participants were included in the adaptive COVID-19 treatment trial (ACTT)-1 or ACTT-2 clinical trials

The author wrote: "In non-severe COVID-19 patients, the increase in the proportion of B cells related to long-term immunity may have an impact on the long-term immunity against SARS-CoV-2 reinfection or the severity of the disease

Thanks

This work was supported by the COVID-19 Pilot Award from UT Health San Antonio Joe R.

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe diseases than after severe diseases

Raphael A.

First published on December 22, 2021, "Public Science Library Comprehensive"

https://doi.

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Article title

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe diseases than after severe diseases

Article publication date

22nd-December-2021