PNAS China University of Science and Technology Tao Yuyong/Li Xu team made a breakthrough in the research on the intracellular-extracellular information transmission mechanism of Staphylococcus aureus

On November 16, 2020, the team of Professor Tao Yuyong and Associate Professor Li Xu of the National Research Center for Microscale Matter Science of the University of Science and Technology of China and the School of Life Sciences published the title "Interface switch mediates signal transmission in a two" online in PNAS, the journal of the National Academy of Sciences.

To adapt to changing environments, bacteria must rapidly translate extracellular information into appropriate intracellular responses

Figure 1 : Structural changes before and after the HptA-HptS signaling system binds to G6P signaling

Taoyu Yong / Li Xu resolves HptA team via structure without substrate binding state and a state of G6P, G6P found that can bind to the gap between the two HptA protein, and can cause two HptA proteins move towards each other

Figure 2 : Possible Activation Mechanisms of the HptA-HptS Signal Transduction System

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Paper link : https://