PNAS: Fever can fight cancer, "small diseases keep getting serious" may not be a rumor

Historically, there have been many examples of cancer patients who have recovered themselves from death

Recently, a research team led by Professor Erika L.

Fever is a common symptom of human inflammation and infection.

In order to simulate the heating process of the human body in vitro, the researchers used anti-CD3/CD28 to activate purified CD8 + T cells at 37°C and 39°C respectively.

Exposure to 39 °C will promote CD8 + TE cell function and anabolism

In addition, CD8+ T cells activated by high temperature will transform from resting naive T cells to fully activated effector T cells, producing cytokines and cytotoxic molecules that can control the growth of pathogens or tumors

Subsequently, the researchers adopted these activated T cells into myeloid leukemia mice, and they were pleasantly surprised to find that the anti-tumor response in the mice was enhanced, and the survival rate of leukemia mice injected with T cells stimulated at 39°C increased significantly.

Exposure to 39 °C can improve T cell metabolism and function in the body

It is well known that mitochondria can regulate the energy level and redox state of cells, and influence the fate of tumor cells through multiple signal transduction pathways, and mitochondrial translation elongation factor 4 (mtEF4) is the "switch" of the process of mitochondrial protein translation.

Therefore, the researchers re-adoptively transferred 39°C T cells treated with mitochondrial translation inhibitor (Antibiotic tigecycline, TIG) into a mouse model of myeloid leukemia, and found that the 39°C T cells treated with TIG had anti-tumor ability in mice.

When mitochondrial translation is impaired, the protective anti-tumor effect of CD8 + TE cells exposed to fever temperature disappears

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