PNAS: Peking University researchers reveal the important role of manganese ions in anti-bacterial natural immunity

On October 9, 2021, the Jiang Zhengfan Laboratory of the School of Life Sciences of Peking University and the Shen Xihui Laboratory of Northwest Agriculture and Forestry University and the Zhou Dongsheng Laboratory of the Military Medical College jointly published their research on antibacterial innate immunity in the internationally renowned academic journal PNAS in the form of Research Article The latest achievement in the field- T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese

This study found that the gram-negative bacterium Y.

TssS chelates manganese ions to inhibit STING-mediated anti-bacterial natural immune response in host cells

Unlike other known bacterial effectors that usually cause disease by interacting with host intracellular proteins, nucleic acids and other macromolecules, this study reveals that a bacterial effector protein can inhibit the host's natural immunity by chelating manganese ions in the host cell.

Postdoctoral fellows Zhu Lingfang and Xu Lei of Northwest University of Agriculture and Forestry Science and Technology, and postdoctoral fellow of Peking University School of Biological Sciences Wang Chenguang are the co-first authors of this paper.