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PNAS: Previously little-known protein involved in metabolic pathway required for cancer cell survival

 Last Update: 2022-01-24
 Source: Internet
 Author: User

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SCP4 is a phosphatase, a protein that regulates cellular activity by removing phosphates from other proteins
.

Another protein called kinase puts these phosphates back

Polyanskaya was surprised to find that only 12 papers in the scientific literature mentioned SCP4
.

None of the papers discussed the role of these proteins in cancer

"It's very interesting when you come across things that have never been studied in the context of cancer before or are not understood at all
.

The researchers believe that SCP4 may control an important metabolic pathway on which AML cells depend
.

Drugs targeting SCP4 can starve and kill cancer cells while allowing other healthy blood cells to grow

Polyanskaya admitted that the decision to study SCP4 was risky
.

But now that its important role in AML cells has been discovered, Polyanskaya said, "Other researchers can use this system, tweak some other things, and really try and pinpoint the exact pathway

Journal Reference :

Sofya A.

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