Premature children with indoor hemorrhage clear the relationship between blood breakdown products in cerebrospinal fluid and hydrocephaline.

Germinal matrix hemorrhage - intra-brain haemorrhage (intra-brain haemorrhage (intravertricational hemorrhage, IVH) is a major cause of disability and death in premature children;
release of decomposition products such as hemoglobin, iron ions and bilirubin after IVH are related to the pathophysiology of hydrocephaline after haemorrhage.
animal experiments have shown that iron affects enlargement of the brain chamber, sea mass injury and poor prognosmation of IVH.
study, conducted by Jennifer M. Strahle of Neurosurgery at the University of Washington School of Medicine, identified the role of blood breakdown products and endogenetic ferro-removal proteins in the pathogenesis of hydrocephalus after IVH in premature children, published online May 2020 in Stroke.
the study, the researchers analyzed 35 premature babies with an average birth age of 30 weeks between 2009 and 2018.
have lumbar punctures for an average of 2 weeks after birth.
35 premature births, including 16 control groups, 4 low-level IVH groups with I-II levels, 6 high-level IVH groups with III-IV levels, and 9 cases of post-hemorrhagic hydrocephalus (PHH) group.
control group were premature babies with a 30-week fetal age and no brain abnormalities or bleeding from head ultrasound, and lumbar punctures were examined for research purposes.
quantitative tests were carried out on hemoglobin, total biliary erythropotin, total iron content, ferrine, copper-blue protein, transirin, binding globin and hemoglobin binding proteins in cerebrospinal fluids.
study found that hemoglobin levels in the cerebrospinal fluid of newborns in the PHH group were significantly higher than those in the control group, the low-level IVH group and the high-level IVH group, where the cerebrospinal hemoglobin content in the PHH group was 9.45 μg/mL, significantly higher than that in the high-level IVH group 6.06?g/mL (P.05).
compared with the control group, the level of ferrin in phH group cerebrospinal fluid (511.33:67.08 ng/mL; P.01) increased significantly, the level of cerebrospinal iron protein in the high-level IVH group also increased significantly, and there was no significant difference between the other blood breakdown products and ferrotranserins detected in cerebrospinal fluid.
In addition, the researchers found a positive correlation between brain chamber enlargement and ferroglobin (Pearson r=0.67), hemoglobin (Pearson r=0.68) and total bililin (Pearson r=0.69), indicating that the concentration of blood breakdown products in cerebrospinal fluid in children with severe enlargement of the brain chamber was high.
characteristic curve analysis of blood decomposition product concentration in cerebrospinal fluid in children with and non-PHH children was also suggested that cerebrospinal fluid hemoglobin content was 6.5 μg/mL (sensitivity 0.88, specificity 0.81) And Jordon index 0.68) and cerebrospinal fluid ferritin content of 555 ng/mL (sensitivity 0.71, specificity 0.89 and Jordon index 0.61) can be used as the risk threshold for PHH occurrence.
conclusion, the results showed that the levels of cerebrospinal hemoglobin and ferroprotein in cerebrospinal fluid after cerebral hemorrhage in premature children were significantly higher than in meninges where hydrocephalus did not occur.
blood breakdown products, such as hemoglobin, ferroprotein, and bilirubin levels, are associated with room size.
several iron removal proteins in the cerebrospinal fluid of premature children with hydrocephalus after haemorrhage did not rise, indicating that hydrocephalus after haemorrhage may be a lesion caused by endogenous iron removal mechanism disorders.
researchers recommend that hemoglobin and ferrine in cerebrospinal fluid be used as potential biomarkers of hydrocephalus after haemorrhage after IVH in premature children; cerebrospinal hemoglobin values of 6.5 μg/mL and cerebrospinal fluid ferrine values of 555 ng/mL indicate a higher risk of hydrocephalus after haemorrhage.
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