Preparation Overview The current status of product development of microsphere injections

Microspheres are solid tiny spheres formed by drugs in a dissolved state or dispersed in a matrix of polymer materials such as gelatin, high molecular weight polypeptides, and proteins, and then processed and solidified.

Selection of carrier materials for microspheres

At present, most of the carrier materials used in the preparation of microspheres are biodegradable substances, which can be roughly divided into two types: natural polymers and synthetic polymers: natural polymers are cheap and have a wide range of sources, and can be divided into polysaccharides and proteins, such as chitosan.

Polylactic acid-polyglycolic acid (PLGA)) and polylactic acid (PLA), which are most widely used in synthetic polymer materials, are polymer materials approved by the FDA for surgical sutures, cardiovascular stents, and controlled-release drug coatings.

Preparation method of microsphere preparation

The preparation method of the microspheres cannot be generalized.

Product development status of microsphere injection

Microsphere injections have developed rapidly in recent years and are playing their unique role in drug delivery systems.

Leuprolide microspheres: Leuprolide is a gonadotropin releasing hormone (GnRH) analog.

Triptorelin microspheres: Triptorelin is also a GnRH analogue, one of the commonly used drugs for gynecological diseases and prostate cancer

Exenatide microspheres: Exenatide is the first glucagon-like peptide-1 analogue approved for marketing in the world.

Octreotide Microspheres and Pasireotide Microspheres: Octreotide Microspheres (Sandostatin Lar) is one of Novartis' leading products

Risperidone microspheres: Risperidal Consta, jointly developed by Alkermes and Johnson & Johnson, is the first long-acting atypical antipsychotic for the treatment of schizophrenia and bipolar disorder, in 2003 Approved by the FDA for marketing, using microsphere technology, the frequency of risperidone administration has been reduced from 1 to 2 times a day to once every 2 weeks

references:

[1] Li Xun, Wei Yi, Ma Guanghui, Hu Linlin.

[2]Wei Lijun.

[3] Zhang Xue, Qi Yiguang, Wu Yujie, Li Zhexiao, Niu Aihua, Liang Yuanyuan, Ren Junle, Tian Liquan, Chen Hong.