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Poly (α-hydroxyacids) were found to be bioabsorble and biocompatible in the 1960s (
1
,
2
). They are the most widely known, studied and used bioabsorbable synthetic polymers in medicine. Polyglycolide (PGA) and poly-
l-lactide (PLLA) homopolymers and their copolymers (PLGA), as well as polylactic acid stereocopolymers produced using
l-,
d-, or
DL-lactides and rasemic polymer copolymer PLDLA are all poly (α-hydroxyacids) (
3
). Poly (α-hydroxy acids) can be polymerized via condensation, although only low mol-wt polymers are produced. In order to obtain a higher mol wt and thus mechanical strength and longer absorption time, the polymers are polymerized from the cyclic dimers via ring-opening polymerization using appropriate initiators and co-initiators. The most commonly used initiator is stannous octoate (
2
,
3
).
