Professor Gu Wei, a Chinese scientist, pioneered a new anti-cancer technique: cure snare nearly 90% of cancer mice.

Chinese scientist Professor Gu Wei has long been committed to the innovative research and development of intelligent drug delivery system, has developed a number of new technologies, including "smart insulin patch", "cancer immunotherapy patch", "weight loss patch" and so on! Recently, its team again issued new results, the first time put forward a "cell joint delivery" technology! Animal trials have shown that the technique can successfully transport anti-cancer drug PD-1 antibodies to the bone marrow, improve the efficacy of the drug, and significantly inhibit the recurrence of the disease.
acute myeloid leukemia (AML) is a cancer that originates in the bone marrow and can spread to the blood and other parts of the body.
as a treatment for leukemia, chemotherapy itself has only moderate effect.
About one-third of leukemia patients who receive chemotherapy do not get remission, and about half of those who receive initial remission relapse, usually within two years of chemotherapy, according to the American Cancer Society.
is usually because some cancer cells are hidden in the bone marrow, and chemotherapy does not "go deep into the bone marrow."
, can we devise a way to deliver drugs directly to the bone marrow? This is a problem that the Gu's team is trying to solve.
1, the first cyto-combination therapy, published october 29 in the journal Nature Biomedical Engineering, entitled "Conjuggation of haematopoie stem and cells with plate-plate-and-disingo-dif-p-d-1 anti-sane-leukaemiaemia-e-leukaemia-e-e- efficacy", they report on a new technology called "Cell Joint Drug Delivery."
CCDD is the first treatment to connect two different cells.
one of the cells is platelets, which are used to deliver antibodies to the immunotherapy drug PD-1.
such drugs can find cancer cells and destroy their defenses, eventually allowing the body's immune system to "see" and destroy them.
", "The platelets are like a van.
we wrap the drug around the cell surface of the platelets and activate them when we reach the target position to 'unload'.
," explains Professor Gu.
another type of stem cell that can lead platelets to the bone marrow (the bone marrow is the sponge tissue in the bone, where new blood cells are produced, and leukemia also originates), i.e. hematopoietic stem cells.
these cells can find access to the bone marrow through special chemical signals. "Hematopoietic stem cells are like a signal to the bone marrow, " said Quanyin Hu, the
's first author.
once stem cells bring a combination of cells (i.e., stem cells and platelets) to the bone marrow, platelets can be activated, releasing drugs and playing an anti-cancer role.
,2, 87.5 percent of mouse animal model studies show that the combination of CCDD injections can prevent further development of the disease in mice with AML.
in the mice treated, 87.5 percent were cured after 80 days.
in addition, two months later (two months after the 80-day period), when the treated mice were injected with leukemia cells, they were resistant to cancer cells. Professor
said CCDD, an innovative treatment, could be used in combination with other therapies, such as chemotherapy and stem cell therapy, to improve their efficacy.
, however, he stressed that the new technology must be tested in human clinical trials and approved by regulators before it can be used to treat leukemia patients.
next, scientists plan to continue to explore the potential of this new technology to treat leukemia and other diseases.
Source: Biological Exploration.