Professor Peng Xichun: The role of bioactive polysaccharide recombinant metastases in alleviating diseases: jaundice polysaccharides improve osteoporosis through DNA methyl group reconstruction

DNA methylation is an overt genetic phenomenon that plays an important role in the occurrence, development and treatment of human diseases. Junsheng Liu, Jun Liu, Xichun Peng, and others from the Department of Food Science and Engineering at Jinan University Polytechnic Institute of Technology studied the exogencic genetic mechanism of jaundice polysaccharide (APS) to improve osteoporosis in rat models.
results showed that APS significantly altered the dna methylation group of colon endoskin cells. Gene enrichment analysis based on differential methylation sites (DMSs) shows that APS causes changes in gene initiation DNA methylation associated with calcium stabilization, bone-breaking cell/osteoblast balance, Wnt signaling, and hormone-related processes. Further analysis showed a high degree of consistency in APS-induced changes in the gene methylation of colon endotylation cells and their effects on diabetes, viral infections and wound healing (relevant studies have been reported). In addition, the researchers proposed new functions and mechanisms of APS in heart disease, neurological diseases, reproductive problems, and olfactory disorders. In this study, the authors provided APS to improve the pregenital genetic mechanisms of osteoporosis. More importantly, a reliable method has been proposed and demonstrated to explore the beneficial effects of bioactive polysaccharides by studying CHANGEs in DNA methylation in non-focus areas. The author thinks that this method is highly efficient, fast and economical, and can explore the possible beneficial or therapeutic effects of functional large molecules through a single experiment.
The author of
Communication, Peng Xichun
, professor and doctoral tutor. Engaged in research on food nutrition components and intestinal health, specifically related to the following aspects: 1) the role of plant functional polysaccharides on chronic diseases; At present, he presides over two projects on the face of the National Natural Science Foundation of China, a number of provincial and ministerial projects and municipal bureau-level projects, and more than 30 horizontal projects of cooperation with enterprises. Won the second prize of the Provincial Science and Technology Progress Award, published more than 30 SCI journal papers, including 1st and 2nd district papers more than 20 articles;
the article "Reprogrammed Epigenetic Landscape-Prophesied Functions of Bioactive Polysaccharides in admaning Diseases: A Pilot Study of DNA Methyl Remodeling in Astragalus Polysaccharide (APS) -Improved Osteoporosis in Rat Model published online at Journal of Agricultural and Food Chemistry.