Professor Zhang Weiguang's research group has made new progress in liver disease research: revealing the relevant metabolic pathways of AQP9 involved in NAFLD

On August 10, 2022, The team of Professor Zhang Weiguang of the School of Basic Medical Sciences of Peking University published online in the Journal of Biological Macromolecules, an authoritative journal in the field of applied chemistry, entitled "Untargeted metabolomics reveals the role of AQP9 in nonalcoholic fatty liver.

The pathogenesis of NAFLD is largely unknown, and so far no approved drugs have been used to prevent or treat NAFLD

Knockout Aqp9 can improve high-fat diet-induced hepatic steatosis

Cheng Quancheng, phD candidate of Peking University School of Basic Medical Sciences, and Zhang Junwei, doctoral candidate of liver surgery at Peking Union Medical College Hospital, are the first authors of the paper, while Professor Zhang Weiguang of Peking University School of Basic Medical Sciences and Professor Lu Xin of Liver Surgery of Peking Union Medical College Hospital are the corresponding authors

Professor Zhang Weiguang's team has long been committed to the study of the mechanism of AQP9 in liver-related diseases, and has achieved a series of scientific research results, not only successfully constructing Aqp9 gene knockout mice, but also exploring its role in chronic liver damage and NAFLD, and has published research papers (2021) in Oxid Med Cell Longev, and published research views on AQP9 related research on Hepatology (2021), in Int J A review related to liver resection was published on Surg (2022

Original link: https://doi.

(Peking University School of Basic Medicine)