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    Home > Medical News > Medical Science News > Progress in research on the pathogenesis of depression

    Progress in research on the pathogenesis of depression

    • Last Update: 2021-09-28
    • Source: Internet
    • Author: User
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    Depression has become one of the major diseases affecting human life, but its pathogenesis is still unclear


    As an important member of the cell membrane-associated guanylate kinase family, the excitatory postsynaptic protein PSD-93 plays an important role in the anchoring, displacement and signal transduction of excitatory postsynaptic receptors


    The study first confirmed the co-localization of PSD-93 and CRH


    This achievement has deepened people's understanding of the neural basis of hypothalamic excitatory synaptic disorders in depression, and promoted the integration of excitatory synaptic hypotheses, stress hypotheses and inflammatory immune hypotheses in the onset of depression


    Related paper information: https://doi.


    https://doi.
    org/10.
    1007/s00401-021-02371-7 https://doi.
    org/10.
    1007/s00401-021-02371-7
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