Progress was made in the study of the active metabolites and fat-lowering mechanisms of sponge co-living hair cells.

Sponge is a porous filter-eating invertebrate, a habitat for a large number of marine microorganisms, and an important part of marine coral reef ecosystem.
Sponge's own physical defense is poor, sponge cogenerant microorganisms are often able to produce active metabolites to assist sponge resistance predators, these metabolites are unique structure, rich in biological activity, marine drugs and their leading compounds are an important source.
The team of Liu Yonghong of the Tropical Marine Life Resources and Ecology Key Laboratory of the South China Sea Ocean Research Institute of the Chinese Academy of Sciences and the Guangdong Marine Medicine Key Laboratory has been engaged in the research of marine microbial activity natural products for a long time, and has recently made progress in the study of the fat reduction mechanism of furan ketones in the secondary metabolites of the hairball cavity fungus, a source of the beautiful genus sponge, taken from Xuwen.
team isolated several novel and diverse polycodone structures from the hairy cell fungus SCSIO41009, of which Setosphalides A and B were the first to find benzodialumide derivatives with 5,5 cycloconzone skeletons, some of which showed antibacterial and antioxidant activity.
the results were published on August 9, 2018 in the Journal of Natural Products.
on this basis, through collaboration with Song Weiguo and Guo Shoudong, professors at weifang Medical College's Center for Innovative Drug Research and Development, researchers conducted a study of the lipid-lowering activity of these polytone structures.
screening of in-body models targeting LXR alpha and PPAR alpha showed that novel furan ketone compounds 5-hydroxy-3-methoxy-5-methyl-4-butylfuran-2 (5H)-one had better cholesterol reduction than the positive controlled drug non-norbert, and the effect of reducing triglycerides was better than L XR alpha agonist T0901317, and cytotoxicity is much lower than positive control T0901317, the mechanism found that the furan ketone compound can promote cholesterol excrete, and can affect the expression of key genes and proteins in cholesterol reverse transport process, thus playing a good fat-lowering activity, the study revealed furan ketone compounds in fat reduction and anti-atherosclerosis in the medicinal value.
results were published recently in the Journal of Cell and Molecular Medicine.
the active screening and mechanism of this study was carried out in collaboration with the Center for Innovative Drug Research and Development of Weifang Medical College.
the above-mentioned work has been supported by the National Natural Science Foundation of China, the Guangdong Provincial Marine Economic Development Special Fund, the Guangdong Science and Technology Project and the Pearl River Nova Project in Guangzhou.
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