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Protein facility users develop neutralizing antibody cocktail therapy against the new coronavirus and reveal the molecular mechanism of its component antibody 2H2/3C1 neutralization

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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Legend: (A) Human-mouse chimeric monoclonal antibodies c3C1, c2H2 and their combinations neutralize live SARS-CoV-2; (BC) chimeric monoclonal antibodies combined in Ad5-ACE2 transduced mouse infection model (Picture B is the relative quantification of viral RNA that infects the lungs of mice (RT-QPCR method); Picture C is a pathological section of the lung); (DE) antibody 2H2 binds to the neocoronavirus S protein trimer A cryo-EM structure with a resolution of 3.

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