Protein "switch" can cut off the blood supply of cancer cells
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Last Update: 2014-11-13
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Source: Internet
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Author: User
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A new study in the UK found that by regulating a signaling protein, it can prevent the formation of new blood vessels around the cancerous tissue of prostate cancer, thus cutting off the nutrition supply pathway of cancer cells and inhibiting the growth and spread of cancer Researchers from the University of Nottingham, the University of Bristol and other institutions reported in the journal carcinogenic genes published on 10 that they have studied vascular endothelial growth factor, a signal protein that can exist in two forms and play two roles, which can not only promote the growth of new blood vessels, but also inhibit their growth The researchers found that prostate cancer cells produce such factors that promote vascular growth, allowing new blood vessels to grow around cancerous tissue, delivering oxygen and other essential nutrients Based on this finding, researchers have developed a compound that can "switch" on and off the formation of vascular endothelial growth factor, allowing the factor to all exist in the form of inhibiting vascular growth In animal experiments, the researchers injected prostate cancer mice with the compound three times a week, and the tumors gradually stopped growing and began to shrink, while the mice did not show significant discomfort (Liu Shilei)
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