Radiology: A new perspective on neuromyelitis optica spectrum diseases: from imaging to clinical

 Spinal cord involvement is a core feature of neuromyelitis optica spectrum disease (NMOSD)
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Traditionally, acute spinal cord injury involves at least three consecutive vertebral body segments, but shorter injuries can also be observed at the same time

 Spinal cord involvement is a core feature of neuromyelitis optica spectrum disease (NMOSD)

Studies have found statistically significant evidence of spinal cord atrophy and neurodegeneration in patients with NMOSD

Recently, a study published in the journal Radiology explored the MRI spatial distribution characteristics of spinal cord T1 hypointensity lesions in patients with NMOSDs and its correlation with spinal cord atrophy and clinical disability, providing a further clinical elucidation of the disease progression and imaging features of NMOSD Valuable reference basis

A total of 52 NMOSDs patients (mean age ± standard deviation, 44 years ± 15 years; 45 women) and 28 age-matched healthy control participants (mean age 44 ± 13 years; 16 women) were included in the study
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Thirty-eight (73%) of 52 patients with NMOSDs had spinal cord injuries with T1 hypointensity

The lesion probability map shows that the lesions mainly involve the upper neck (C2-C4) and upper chest (T1-T3 level), the more severe the spinal cord C1-C4 is injured (P value range, .

Figure This figure shows the T1 hypointensity lesion probability map and local atrophy
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Sagittal and axial display the probability map of T1 hypointensity lesions at each spinal cord level plus the posterior spinal area (AP) (left side, the threshold only retains pixels with a probability of ≥30% including the lesion; the rainbow-colored scale represents the frequency Value), sagittal and axial plots show that AP is added at the level of each spinal cord compared with the healthy control group (right side; the color scale from yellow to brown indicates the t value)

Figure This figure shows the T1 hypointensity lesion probability map and local atrophy

Table T1 low signal lesion volume in the GM and WM area distribution between vertebral body segments
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Table T1 low signal lesion volume in the GM and WM area distribution between vertebral body segments
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This study shows that in optic neuromyelitis spectrum diseases, myelopathy is mainly distributed in the upper cervical spinal cord and gray matter on MRI, and is related to spinal cord atrophy and clinical disability.
It is a clinical understanding of the mechanism of neuromyelitis spectrum diseases.
And accurate identification and treatment provide new ideas and open the way for further related research
.

This study shows that in optic neuromyelitis spectrum diseases, myelopathy is mainly distributed in the upper cervical spinal cord and gray matter on MRI, and is related to spinal cord atrophy and clinical disability.
It is a clinical understanding of the mechanism of neuromyelitis spectrum diseases.
And accurate identification and treatment provide new ideas and open the way for further related research
.

Original source:

Original source:

Laura Cacciaguerra , Paola Valsasina , Sarlota Mesaros ,et

Laura Cacciaguerra , Paola Valsasina , Sarlota Mesaros ,et

al.

al.

DOI: 10.
1148/radiol.
2020192664 10.
1148/radiol.
2020192664 Leave a message here