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Radiotherapy and Oncology: The influence of DNA repair and reactive oxygen levels on the radiation resistance of pancreatic cancer

 Last Update: 2021-05-08
 Source: Internet
 Author: User

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Pancreatic cancer is a devastating disease with a 5-year survival rate of less than 5%.

Pancreatic cancer diagnosis

The radiation resistance of pancreatic cancer patients is still a key obstacle to overcome.

The human pancreatic cancer cell lines Panc-1 and MIA PaCa-2 were repeatedly exposed to radiation to generate radiation-resistant (RR) and other genetic cell lines.

FDA

The radioresistance of the obtained RR cell line was proved in vitro and verified in vivo.

The data from this study shows that repeated exposure to radiation increases the expression of genes involved in cell viability, leading to radioresistance.

Repeated exposure to radiation increases the expression of genes involved in cell viability, leading to radioresistance.

Original source

Nguyen L, Dobiasch S, Schneider G, et al.

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