Rare genetic mutation sepsis may prevent Alzheimer's disease

The cause of most Alzheimer's disease is not yet clearHowever, a small number of people who carry a specific mutation in the presenilin 1 protein gene are more likely to develop Alzheimer's disease and develop cognitive problems and dementia at a particularly young age, usually in their 40sthe study, a woman's brain had a higher degree of pathological changes in amyloid, a major feature of Alzheimer's diseaseHowever, the woman did not show symptoms associated with the diseaseScientists at Massachusetts General Hospital, the Schepens Eye Institute at Massachusetts Eye and Ear Hospital, and the Department of Ophthalmology at Harvard Medical School and the Banner Alzheimer's Research Institute studied her genome and found that in addition to the disease-causing mutation, she carried a rare mutation in the APOE gene called Christchurchresearchers believe the mutation may have offset the harmful effects of the oxytocin 1 mutation, which caused the woman's brain to change amyloid pathology to a high degree, but did not develop the diseaseThe woman's cognitive health remained in her 70sAfter several experiments, the team believes the mutation may have disrupted the combination of APOE and Alzheimer's-related sugars, creating a protective effecttheteam concluded that the case study provided new insights into the mechanisms for the development, treatment and potential prevention of Alzheimer's disease and provided the first known candidate gene for the development of interventions to block disease progression(Reporter Zhang Mengran)editor-in-chief circle pointthe treatment of Alzheimer's disease, in recent days due to the chinese invention of new drugs on the market, has become a hot topic of public opinionHowever, at present, a variety of therapies together, can only delay the disease, can not be curedPerhaps gene therapy will be a complete solutionAlthough Alzheimer's disease afflicts a significant proportion of the population, the genes that fight it have not spread, which may be because the onset is largely in old age, which is not conducive to the advantage of the anti-disease geneArtificial intervention may allow newly discovered anti-disease genes to show their power in more cases.