Recruitment notice Bifidobacterium lactis M8 on the nutritional intervention of children with autism

Parents: We sincerely invite you and your children to participate in the Inner Mongolia Autonomous Region Science and Technology Major Special Project—"Probiotic Lactobacillus Screening, Functional Evaluation and Industrialization Technology Integration for Preventing and Improving Metabolic Diseases" Scientific Research Project (Project No. ZDZX8018, start and end date 2018-2021) sub-project: "Bifidobacterium lactis M8+ low-carbon balanced diet for children with autism nutrition intervention research" project, implemented by the clinical nutrition department, this research has been reviewed by the ethics committee of Shenzhen Hospital of Southern Medical University And approved . Expert team introduction Professor Zhang Heping, China Probiotics "Pioneer" National Outstanding Youth Science Fund Winner, "Changjiang Scholar" Award Program Distinguished Professor, Director of the Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education Professor Zhu Cuifeng 30 years of clinical teaching and research work experience Member of the Chinese Medical Association Parenteral and Enteral Nutrition Branch Member of the National Health Commission National Clinical Nutrition Quality Control Center Director of the Department of Nutrition, Southern Medical University Shenzhen Hospital   Dean Shao Jianzhong has been engaged in clinical medicine for 22 years, a national first-level nutritionist, professional qualification in nutrition from Cambridge, UK, focusing on integrated medical research for children with autism 　　Background Introduction 　　Changes in the intestinal flora have been proven to greatly affect mood, pain tolerance, cognitive ability, behavior and mental health . The imbalance of the intestinal flora can cause many neurological problems, such as depression . Research results show that the imbalance of intestinal flora is related to neurodevelopmental problems such as autism . This discovery earned the entire intestine the nickname "Second Brain" . 　　There is increasing evidence that the intestinal flora may be a key factor in nervous system disorders, including Alzheimer's disease and autism . The intestinal flora can influence the physiological structure, speech expression and social behavior of the brain through the "brain-gut axis" . The flora metabolites and various neurotransmitters produced in the intestine can send signals to the brain . 　　In the clinical cases of children with autism who were diagnosed with autism, it was found that autism, including developmental delay, and the intestinal tract are extremely closely related. , And achieved a curative effect beyond expectations . According to the research results recently published by CUHK: 　　(1) There are five types of bacteria in the intestines of children with autism, which are relatively rare in the intestines of ordinary children . The sensitivity of the five fecal bacterial genes to identify children with autism is as high as 80% . 　　(2) Stool samples of children with autism contain more clostridia, which can produce toxins and damage the central nervous system . 　　(3) Beneficial bacteria related to neurotransmitter activity are greatly reduced in the intestines of children with autism . 　　(4) The types and data of the intestinal flora should have changed with age, but clinically, it has been found that the intestinal flora of children with autism is significantly lagging behind compared with children of the same age . 　　In nearly a thousand cases of Juju therapy, adjusting the balance of intestinal flora can significantly improve the behavior of children in cognitive, social, speech and other behaviors. Further research on flora conditioning may provide new treatment methods for the children you are monitoring and children with these diseases, and may achieve new curative effects and progress in improving the physiological symptoms and behavioral performance of autism . 　　Introduction of M8 Probiotics 　　Bifidobacterium lactis M8, also called active M8 probiotics derived from breast milk . It is a probiotic strain with potential probiotic properties selected from 364 strains of lactic acid bacteria and bifidobacteria isolated from 84 breast milks of healthy women in China in 2017. Species collection center, the deposit number is cgmccno. 18610 . Bifidobacterium lactis M8 has good tolerance to gastrointestinal digestive juices and can enter the human intestines in a live state. It has probiotic features such as enhancing immune resistance, improving the diversity of intestinal flora, and increasing the stability of intestinal flora. . 　　In the special issue of the 2021 China Intestinal Conference (Issue 1832), it has been clearly pointed out that M8 can be used for the treatment of hospitalized infants with respiratory infections, intestinal diseases, and Parkinson's syndrome . Clinical application and third-party safety evaluation have confirmed that the probiotic is safe and non-toxic . 　　Previous laboratory data and clinical experiments have shown that Bifidobacterium lactis M8 can significantly improve cognition, behavioral stereotypes, social behavior and other behavioral problems . 　　Inclusion criteria 　　(1) Diagnosed with autism according to the 5th edition of the DSM diagnostic criteria, and excluded secondary autism, such as abnormal metabolism and brain structure; 　　(2) Age: 3-12 years old, gender is not limited ; 　　(3) received an oral Bifidobacterium lactis containing M8 and lower guide balanced diet; 　　(4) according to the protocol to require the completion of study; 　　(5) without a known immunodeficiency diseases; 　　(6) Stop using various antibacterial drugs, diet therapy, immunosuppressive drugs, high-dose vitamins and other simultaneous drug treatments for more than 1 month, and have not taken probiotics; 　　(7) Patients living in Huzhou, Zhejiang Children are given priority; 　　(8) Volunteer to participate in this application treatment, parents (guardians) signed informed consent, and can adhere to the treatment follow-up . The parents of the child are healthy, and there are no diseases that seriously affect normal life, work, thinking, and judgment . 　　Exclusion criteria 　　(1) Diagnosed as severe malnutrition; 　　(2) Suffered from a serious gastrointestinal disease (or life-threatening) that requires immediate treatment 　　(3) Has a single-gene disease; 　　(4) Has a history of severe allergies; 　　(5) Had severe fever and/or severe infection within 7 days before enrollment; 　　(6) Children with renal insufficiency and liver dysfunction (or creatinine>2mg/dl, direct bilirubin>2mg/dl); 　　(7) Suffer from inflammatory bowel disease, intestinal obstruction, intestinal perforation, intestinal bleeding, celiac disease, irritable bowel syndrome or eosinophilia, esophagitis, eosinophilic gastroenteritis or similar conditions; 　　( 8) Children with severe sensory or motor problems (eg blindness, deafness, seizures, cerebral palsy) 　　(9) Participating in other clinical application research, or receiving other interventional clinical research interventions within 4 weeks before enrollment ; 　　(10) continued to take probiotics in children . 　　(11) Children with organic nervous system diseases and other diseases that seriously affect the quality of life, and are accompanied by genetic diseases of ASD (fragile X syndrome, tuberous sclerosis) . 　　Children's benefits 　　According to previous studies, intestinal flora conditioning and transplantation in the treatment of autism are likely to achieve breakthrough effects, which will bring new treatment hopes to children and provide new opportunities and data for future autism treatment . 　　In addition, participating in this application research will get: 　　(1) The differential diagnosis of the disease by an experienced clinical medical expert group; 　　(2) A systematic free assessment of all aspects of autism worth more than RMB 2,000, and intestinal bacteria worth RMB 8,400 Group free testing and analysis, which will be of great significance to the guidance of rehabilitation treatment for children in the future; 　　(3) After the clinical application treatment, children will receive 6-month probiotic products worth over 6000 yuan as well as gifts. 1000-10,000 yuan Jutherapy Rehabilitation Medical Center Inpatient Rehabilitation Fund, enter the Jutherapy Rehabilitation Medical Center for systemic treatment, and enjoy the VIP treatment plan and the opportunity of personal consultation by the dean . 　　Contact and other 　　Recruitment location: 　　Jutherapy 　　Rehabilitation Medical Center (Building 3, No. 4888 Taihu Road, Binhu Street, South Taihu District, Huzhou City, Zhejiang Province) 　　Contact: Dr. Zhong 15314834228 　　Wang Qianqian 158 2182 7964 　　Zhu Cuifeng 0755 23360180 *The above information is only for Jutherapy The Autism Clinical Application Group of the Rehabilitation Medical Center recruits children with autism for the rehabilitation of children with autism. 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Parents:

　　We sincerely invite you and your children to participate in the Inner Mongolia Autonomous Region Science and Technology Major Special Project—"Probiotic Lactobacillus Screening, Functional Evaluation and Industrialization Technology Integration for Preventing and Improving Metabolic Diseases" Scientific Research Project (Project No.
ZDZX8018, start and end date 2018-2021) sub-project: "Bifidobacterium lactis M8+ low-carbon balanced diet for children with autism nutrition intervention research" project, implemented by the clinical nutrition department, this research has been reviewed by the ethics committee of Shenzhen Hospital of Southern Medical University And approved
.


　　Expert team introduction




　　Background Introduction

　　Changes in the intestinal flora have been proven to greatly affect mood, pain tolerance, cognitive ability, behavior and mental health
.
The imbalance of the intestinal flora can cause many neurological problems, such as depression
.
Research results show that the imbalance of intestinal flora is related to neurodevelopmental problems such as autism
.
This discovery earned the entire intestine the nickname "Second Brain"
.


　　There is increasing evidence that the intestinal flora may be a key factor in nervous system disorders, including Alzheimer's disease and autism
.
The intestinal flora can influence the physiological structure, speech expression and social behavior of the brain through the "brain-gut axis"
.
The flora metabolites and various neurotransmitters produced in the intestine can send signals to the brain
.


　　In the clinical cases of children with autism who were diagnosed with autism, it was found that autism, including developmental delay, and the intestinal tract are extremely closely related.
, And achieved a curative effect beyond expectations
.
According to the research results recently published by CUHK:

　　(1) There are five types of bacteria in the intestines of children with autism, which are relatively rare in the intestines of ordinary children
.
The sensitivity of the five fecal bacterial genes to identify children with autism is as high as 80%
.


　　(2) Stool samples of children with autism contain more clostridia, which can produce toxins and damage the central nervous system
.


　　(3) Beneficial bacteria related to neurotransmitter activity are greatly reduced in the intestines of children with autism
.


　　(4) The types and data of the intestinal flora should have changed with age, but clinically, it has been found that the intestinal flora of children with autism is significantly lagging behind compared with children of the same age
.


　　In nearly a thousand cases of Juju therapy, adjusting the balance of intestinal flora can significantly improve the behavior of children in cognitive, social, speech and other behaviors.
Further research on flora conditioning may provide new treatment methods for the children you are monitoring and children with these diseases, and may achieve new curative effects and progress in improving the physiological symptoms and behavioral performance of autism
.


　　Introduction of M8 Probiotics

　　Bifidobacterium lactis M8, also called active M8 probiotics derived from breast milk
.
It is a probiotic strain with potential probiotic properties selected from 364 strains of lactic acid bacteria and bifidobacteria isolated from 84 breast milks of healthy women in China in 2017.
Species collection center, the deposit number is cgmccno.
18610
.
Bifidobacterium lactis M8 has good tolerance to gastrointestinal digestive juices and can enter the human intestines in a live state.
It has probiotic features such as enhancing immune resistance, improving the diversity of intestinal flora, and increasing the stability of intestinal flora.

.


　　In the special issue of the 2021 China Intestinal Conference (Issue 1832), it has been clearly pointed out that M8 can be used for the treatment of hospitalized infants with respiratory infections, intestinal diseases, and Parkinson's syndrome
.
Clinical application and third-party safety evaluation have confirmed that the probiotic is safe and non-toxic
.


　　Previous laboratory data and clinical experiments have shown that Bifidobacterium lactis M8 can significantly improve cognition, behavioral stereotypes, social behavior and other behavioral problems
.


　　Inclusion criteria

　　(1) Diagnosed with autism according to the 5th edition of the DSM diagnostic criteria, and excluded secondary autism, such as abnormal metabolism and brain structure;
　　(2) Age: 3-12 years old, gender is not limited ;
　　(3) received an oral Bifidobacterium lactis containing M8 and lower guide balanced diet;
　　(4) according to the protocol to require the completion of study;
　　(5) without a known immunodeficiency diseases;
　　(6) Stop using various antibacterial drugs, diet therapy, immunosuppressive drugs, high-dose vitamins and other simultaneous drug treatments for more than 1 month, and have not taken probiotics;
　　(7) Patients living in Huzhou, Zhejiang Children are given priority;
　　(8) Volunteer to participate in this application treatment, parents (guardians) signed informed consent, and can adhere to the treatment follow-up
.
The parents of the child are healthy, and there are no diseases that seriously affect normal life, work, thinking, and judgment
.


　　Exclusion criteria

　　(1) Diagnosed as severe malnutrition;
　　(2) Suffered from a serious gastrointestinal disease (or life-threatening) that requires immediate treatment
　　(3) Has a single-gene disease;
　　(4) Has a history of severe allergies;
　　(5) Had severe fever and/or severe infection within 7 days before enrollment;
　　(6) Children with renal insufficiency and liver dysfunction (or creatinine>2mg/dl, direct bilirubin>2mg/dl);
　　(7) Suffer from inflammatory bowel disease, intestinal obstruction, intestinal perforation, intestinal bleeding, celiac disease, irritable bowel syndrome or eosinophilia, esophagitis, eosinophilic gastroenteritis or similar conditions;
　　( 8) Children with severe sensory or motor problems (eg blindness, deafness, seizures, cerebral palsy)
　　(9) Participating in other clinical application research, or receiving other interventional clinical research interventions within 4 weeks before enrollment ;
　　(10) continued to take probiotics in children
.

　　(11) Children with organic nervous system diseases and other diseases that seriously affect the quality of life, and are accompanied by genetic diseases of ASD (fragile X syndrome, tuberous sclerosis)
.


　　Children's benefits

　　According to previous studies, intestinal flora conditioning and transplantation in the treatment of autism are likely to achieve breakthrough effects, which will bring new treatment hopes to children and provide new opportunities and data for future autism treatment
.


　　In addition, participating in this application research will get:
　　(1) The differential diagnosis of the disease by an experienced clinical medical expert group;
　　(2) A systematic free assessment of all aspects of autism worth more than RMB 2,000, and intestinal bacteria worth RMB 8,400 Group free testing and analysis, which will be of great significance to the guidance of rehabilitation treatment for children in the future;
　　(3) After the clinical application treatment, children will receive 6-month probiotic products worth over 6000 yuan as well as gifts.
1000-10,000 yuan Jutherapy Rehabilitation Medical Center Inpatient Rehabilitation Fund, enter the Jutherapy Rehabilitation Medical Center for systemic treatment, and enjoy the VIP treatment plan and the opportunity of personal consultation by the dean
.


　　Contact and other

　　Recruitment location: 　　Jutherapy

　　Rehabilitation Medical Center (Building 3, No.
4888 Taihu Road, Binhu Street, South Taihu District, Huzhou City, Zhejiang Province)

　　Contact:

Dr.
Zhong 15314834228
　　Wang Qianqian 158 2182 7964
　　Zhu Cuifeng 0755 23360180

*The above information is only for Jutherapy The Autism Clinical Application Group of the Rehabilitation Medical Center recruits children with autism for the rehabilitation of children with autism.
It is not used for other purposes without permission.
The right of interpretation belongs to the Jutherapy Rehabilitation Medical Center
.

---

Parents:

　　We sincerely invite you and your children to participate in the Inner Mongolia Autonomous Region Science and Technology Major Special Project—"Probiotic Lactobacillus Screening, Functional Evaluation and Industrialization Technology Integration for Preventing and Improving Metabolic Diseases" Scientific Research Project (Project No.
ZDZX8018, start and end date 2018-2021) sub-project: "Bifidobacterium lactis M8+ low-carbon balanced diet for children with autism nutrition intervention research" project, implemented by the clinical nutrition department, this research has been reviewed by the ethics committee of Shenzhen Hospital of Southern Medical University And approved
.


　　Expert team introduction




　　Background Introduction

　　Changes in the intestinal flora have been proven to greatly affect mood, pain tolerance, cognitive ability, behavior and mental health
.
The imbalance of the intestinal flora can cause many neurological problems, such as depression
.
Research results show that the imbalance of intestinal flora is related to neurodevelopmental problems such as autism
.
This discovery earned the entire intestine the nickname "Second Brain"
.


　　There is increasing evidence that the intestinal flora may be a key factor in nervous system disorders, including Alzheimer's disease and autism
.
The intestinal flora can influence the physiological structure, speech expression and social behavior of the brain through the "brain-gut axis"
.
The flora metabolites and various neurotransmitters produced in the intestine can send signals to the brain
.


　　In the clinical cases of children with autism who were diagnosed with autism, it was found that autism, including developmental delay, and the intestinal tract are extremely closely related.
, And achieved a curative effect beyond expectations
.
According to the research results recently published by CUHK:

　　(1) There are five types of bacteria in the intestines of children with autism, which are relatively rare in the intestines of ordinary children
.
The sensitivity of the five fecal bacterial genes to identify children with autism is as high as 80%
.


　　(2) Stool samples of children with autism contain more clostridia, which can produce toxins and damage the central nervous system
.


　　(3) Beneficial bacteria related to neurotransmitter activity are greatly reduced in the intestines of children with autism
.


　　(4) The types and data of the intestinal flora should have changed with age, but clinically, it has been found that the intestinal flora of children with autism is significantly lagging behind compared with children of the same age
.


　　In nearly a thousand cases of Juju therapy, adjusting the balance of intestinal flora can significantly improve the behavior of children in cognitive, social, speech and other behaviors.
Further research on flora conditioning may provide new treatment methods for the children you are monitoring and children with these diseases, and may achieve new curative effects and progress in improving the physiological symptoms and behavioral performance of autism
.


　　Introduction of M8 Probiotics

　　Bifidobacterium lactis M8, also called active M8 probiotics derived from breast milk
.
It is a probiotic strain with potential probiotic properties selected from 364 strains of lactic acid bacteria and bifidobacteria isolated from 84 breast milks of healthy women in China in 2017.
Species collection center, the deposit number is cgmccno.
18610
.
Bifidobacterium lactis M8 has good tolerance to gastrointestinal digestive juices and can enter the human intestines in a live state.
It has probiotic features such as enhancing immune resistance, improving the diversity of intestinal flora, and increasing the stability of intestinal flora.

.


　　In the special issue of the 2021 China Intestinal Conference (Issue 1832), it has been clearly pointed out that M8 can be used for the treatment of hospitalized infants with respiratory infections, intestinal diseases, and Parkinson's syndrome
.
Clinical application and third-party safety evaluation have confirmed that the probiotic is safe and non-toxic
.


　　Previous laboratory data and clinical experiments have shown that Bifidobacterium lactis M8 can significantly improve cognition, behavioral stereotypes, social behavior and other behavioral problems
.


　　Inclusion criteria

　　(1) Diagnosed with autism according to the 5th edition of the DSM diagnostic criteria, and excluded secondary autism, such as abnormal metabolism and brain structure;
　　(2) Age: 3-12 years old, gender is not limited ;
　　(3) received an oral Bifidobacterium lactis containing M8 and lower guide balanced diet;
　　(4) according to the protocol to require the completion of study;
　　(5) without a known immunodeficiency diseases;
　　(6) Stop using various antibacterial drugs, diet therapy, immunosuppressive drugs, high-dose vitamins and other simultaneous drug treatments for more than 1 month, and have not taken probiotics;
　　(7) Patients living in Huzhou, Zhejiang Children are given priority;
　　(8) Volunteer to participate in this application treatment, parents (guardians) signed informed consent, and can adhere to the treatment follow-up
.
The parents of the child are healthy, and there are no diseases that seriously affect normal life, work, thinking, and judgment
.


　　Exclusion criteria

　　(1) Diagnosed as severe malnutrition;
　　(2) Suffered from a serious gastrointestinal disease (or life-threatening) that requires immediate treatment
　　(3) Has a single-gene disease;
　　(4) Has a history of severe allergies;
　　(5) Had severe fever and/or severe infection within 7 days before enrollment;
　　(6) Children with renal insufficiency and liver dysfunction (or creatinine>2mg/dl, direct bilirubin>2mg/dl);
　　(7) Suffer from inflammatory bowel disease, intestinal obstruction, intestinal perforation, intestinal bleeding, celiac disease, irritable bowel syndrome or eosinophilia, esophagitis, eosinophilic gastroenteritis or similar conditions;
　　( 8) Children with severe sensory or motor problems (eg blindness, deafness, seizures, cerebral palsy)
　　(9) Participating in other clinical application research, or receiving other interventional clinical research interventions within 4 weeks before enrollment ;
　　(10) continued to take probiotics in children
.

　　(11) Children with organic nervous system diseases and other diseases that seriously affect the quality of life, and are accompanied by genetic diseases of ASD (fragile X syndrome, tuberous sclerosis)
.


　　Children's benefits

　　According to previous studies, intestinal flora conditioning and transplantation in the treatment of autism are likely to achieve breakthrough effects, which will bring new treatment hopes to children and provide new opportunities and data for future autism treatment
.


　　In addition, participating in this application research will get:
　　(1) The differential diagnosis of the disease by an experienced clinical medical expert group;
　　(2) A systematic free assessment of all aspects of autism worth more than RMB 2,000, and intestinal bacteria worth RMB 8,400 Group free testing and analysis, which will be of great significance to the guidance of rehabilitation treatment for children in the future;
　　(3) After the clinical application treatment, children will receive 6-month probiotic products worth over 6000 yuan as well as gifts.
1000-10,000 yuan Jutherapy Rehabilitation Medical Center Inpatient Rehabilitation Fund, enter the Jutherapy Rehabilitation Medical Center for systemic treatment, and enjoy the VIP treatment plan and the opportunity of personal consultation by the dean
.


　　Contact and other

　　Recruitment location: 　　Jutherapy

　　Rehabilitation Medical Center (Building 3, No.
4888 Taihu Road, Binhu Street, South Taihu District, Huzhou City, Zhejiang Province)

　　Contact:

Dr.
Zhong 15314834228
　　Wang Qianqian 158 2182 7964
　　Zhu Cuifeng 0755 23360180

*The above information is only for Jutherapy The Autism Clinical Application Group of the Rehabilitation Medical Center recruits children with autism for the rehabilitation of children with autism.
It is not used for other purposes without permission.
The right of interpretation belongs to the Jutherapy Rehabilitation Medical Center
.

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