Regarding the B.1.617 new coronavirus variant, these research progress has been announced

Since its outbreak at the end of 2019, the new coronavirus (referred to as the new coronavirus or SARS-CoV-2) has ravaged the world
.

So how did the B.
1.
617 mutant virus strain appear? How effective are the existing vaccines to protect it? With these questions, let's sort out the recent progress
.

B.
1.
617-Two key mutations, L452R and E484Q, improve transmission and immune escape capabilities

The B.
1.
617 mutant virus strain was first discovered in India as early as October 2020
.

B.
1.
617 The gene mutation carried by the mutant strain (Source: Reference 1)

       Does the vaccine have the ability to protect against B.
1.
617?

       There are not many studies on the protective ability of existing vaccines against B.
1.
617
.

       In addition, Public Health England (PHE) recently announced research results based on its domestic real data, showing that two doses of the new crown vaccine can produce a high degree of protection against the B.
1.
617.
2 mutant strain
.

       The results of the study showed that two weeks after inoculation with two injections of the mRNA vaccine jointly developed by Pfizer/BioNTech, the effectiveness of preventing symptomatic COVID-19 caused by B.
1.
617.
2 infection was 88%, and the prevention was because of B.
1.
1.
7.
The effectiveness of symptomatic COVID-19 infection is 93%
.

       After being vaccinated with two injections of the adenovirus vaccine jointly developed by AstraZeneca and Oxford University, the effectiveness of preventing symptomatic COVID-19 caused by B.
1.
617.
2 infection is 60%, and it is effective in preventing B.
1.
1.
7 infection.
The effectiveness of symptomatic COVID-19 is 66%
.

       The study also found that if only one dose of the vaccine is vaccinated, the protective ability of the mutant strain is significantly reduced
.

       The results of the study show that the completion of two doses of vaccination is critical to obtaining maximum protection
.

       With the development of the new crown pandemic, more and more new crown mutant virus strains have appeared.
For example, in addition to the Indian strains, there are also South African strains, British strains, and Brazilian strains.
The escape ability of neutralizing antibodies has been improved.
Therefore, it is urgent to develop new treatment strategies, such as new bispecific antibodies
.

       RB-100 is a new type of bispecific antibody that can specifically target two different sites on the spike protein of the new coronavirus.
Therefore, compared with monoclonal antibodies that bind to a single epitope, RB-100 presents Higher resistance barrier
.

       As a new coronavirus mutant strain with a short epidemic time and complicated mutation and escape mechanisms , although studies have now elucidated its mechanism and prevention and control, it still leaves us with many questions
.

       Reference source:

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