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Recently, the Department of Bioinformatics and Biostatistics, School of Life Science and Technology , Shanghai Jiaotong University, and the team from the Shanghai Jiao Tong University -Yale Joint Center for Biostatistics and Data Science published a titled Association of HIV-infection in "Ageing Research Reviews" (IF: 10.
616) and Cognitive Impairment in Older Adults: A Meta-analysis of meta-analysis works.
First-year doctoral student Deng Luojia and undergraduate student Xuezhi Zhang of Shanghai Jiaotong University School of Life Sciences and Technology are co-first authors, Professor Qian Hanzhu of Yale University and Associate Researcher Zhang Yue of Shanghai Jiaotong University are the co-corresponding authors, Shanghai Jiaotong University Life Science and Technology The Department of Bioinformatics and Biostatistics of the College is the first communication unit for this article.
Gao Yanxiao, a doctoral student at Sun Yale University, DeAnne Turner, a postdoctoral fellow at Yale University, Dr.
Frank Qian from Harvard Medical School, Professor Lu Hui from Shanghai Jiaotong University, and Professor Sten H.
Vermund from Yale University are co-authors.
The main work of the study was completed by the two co-first authors at the undergraduate level.
The study used meta-analysis to integrate existing empirical evidence to study the relationship between HIV infection and cognitive impairment in the elderly.
616) and Cognitive Impairment in Older Adults: A Meta-analysis of meta-analysis works.
First-year doctoral student Deng Luojia and undergraduate student Xuezhi Zhang of Shanghai Jiaotong University School of Life Sciences and Technology are co-first authors, Professor Qian Hanzhu of Yale University and Associate Researcher Zhang Yue of Shanghai Jiaotong University are the co-corresponding authors, Shanghai Jiaotong University Life Science and Technology The Department of Bioinformatics and Biostatistics of the College is the first communication unit for this article.
Gao Yanxiao, a doctoral student at Sun Yale University, DeAnne Turner, a postdoctoral fellow at Yale University, Dr.
Frank Qian from Harvard Medical School, Professor Lu Hui from Shanghai Jiaotong University, and Professor Sten H.
Vermund from Yale University are co-authors.
The main work of the study was completed by the two co-first authors at the undergraduate level.
The study used meta-analysis to integrate existing empirical evidence to study the relationship between HIV infection and cognitive impairment in the elderly.
With the popularization of highly active antiretroviral therapy (HAART), HIV-related mortality has been greatly reduced, and the average life expectancy of HIV-infected persons (PLWH) has also been extended.
The number of elderly PLWH is on the rise, which is related to age Comorbidities (including increased risk of cognitive impairment) have become the main focus of HIV care.
Some existing studies have found that HIV may damage neurons and cause HIV-related neurological diseases (HAND) or HIV-related dementia (HAD), but ART treatment may reduce the incidence of HAD and cause mild neurocognitive impairment (MND) The high morbidity rate.
Both aging and HIV infection (that is, the medical side effects and neurological effects of long-term HIV infection) may adversely affect the cognitive health of elderly PLWH, and HIV infection may also have different effects on specific cognitive domains.
Prior to this, few articles specifically studied the cognitive impairment of PLWH and the performance of various cognitive domains for the elderly.
The results of this study show that compared with controls without HIV infection, elderly PLWH are more likely to develop cognitive impairment (OR=2.
44), and are more likely to have cognitive impairment in executive function, processing speed, language, recall, and motor/psychomotor.
The domains are significantly different.
The number of elderly PLWH is on the rise, which is related to age Comorbidities (including increased risk of cognitive impairment) have become the main focus of HIV care.
Some existing studies have found that HIV may damage neurons and cause HIV-related neurological diseases (HAND) or HIV-related dementia (HAD), but ART treatment may reduce the incidence of HAD and cause mild neurocognitive impairment (MND) The high morbidity rate.
Both aging and HIV infection (that is, the medical side effects and neurological effects of long-term HIV infection) may adversely affect the cognitive health of elderly PLWH, and HIV infection may also have different effects on specific cognitive domains.
Prior to this, few articles specifically studied the cognitive impairment of PLWH and the performance of various cognitive domains for the elderly.
The results of this study show that compared with controls without HIV infection, elderly PLWH are more likely to develop cognitive impairment (OR=2.
44), and are more likely to have cognitive impairment in executive function, processing speed, language, recall, and motor/psychomotor.
The domains are significantly different.
The public health significance of this study is that the results of this study provide a better understanding of the cognitive status of elderly PLWH, especially those cognitive domains that perform significantly worse in PLWH.
Therefore, in the elderly PLWH, we should not only pay attention to the HIV treatment itself, but also the potential cognitive decline.
Conducting cognitive tests will help early detection of cognitive decline in elderly PLWH, specific cognitive areas (such as executive Function, exercise/mental movement, processing speed, etc.
) can be targeted for treatment and cognitive training to improve the cognitive status and quality of life of elderly PLWH.
(Bioon.
com)
Therefore, in the elderly PLWH, we should not only pay attention to the HIV treatment itself, but also the potential cognitive decline.
Conducting cognitive tests will help early detection of cognitive decline in elderly PLWH, specific cognitive areas (such as executive Function, exercise/mental movement, processing speed, etc.
) can be targeted for treatment and cognitive training to improve the cognitive status and quality of life of elderly PLWH.
(Bioon.
com)
Recently, the Department of Bioinformatics and Biostatistics, School of Life Science and Technology , Shanghai Jiaotong University, and the team from the Shanghai Jiao Tong University -Yale Joint Center for Biostatistics and Data Science published a titled Association of HIV-infection in "Ageing Research Reviews" (IF: 10.
616) and Cognitive Impairment in Older Adults: A Meta-analysis of meta-analysis works.
First-year doctoral student Deng Luojia and undergraduate student Xuezhi Zhang of Shanghai Jiaotong University School of Life Sciences and Technology are co-first authors, Professor Qian Hanzhu of Yale University and Associate Researcher Zhang Yue of Shanghai Jiaotong University are the co-corresponding authors, Shanghai Jiaotong University Life Science and Technology The Department of Bioinformatics and Biostatistics of the College is the first communication unit for this article.
Gao Yanxiao, a doctoral student at Sun Yale University, DeAnne Turner, a postdoctoral fellow at Yale University, Dr.
Frank Qian from Harvard Medical School, Professor Lu Hui from Shanghai Jiaotong University, and Professor Sten H.
Vermund from Yale University are co-authors.
The main work of the study was completed by the two co-first authors at the undergraduate level.
The study used meta-analysis to integrate existing empirical evidence to study the relationship between HIV infection and cognitive impairment in the elderly.
Bioinformatics Bioinformatics616) and Cognitive Impairment in Older Adults: A Meta-analysis of meta-analysis works.
First-year doctoral student Deng Luojia and undergraduate student Xuezhi Zhang of Shanghai Jiaotong University School of Life Sciences and Technology are co-first authors, Professor Qian Hanzhu of Yale University and Associate Researcher Zhang Yue of Shanghai Jiaotong University are the co-corresponding authors, Shanghai Jiaotong University Life Science and Technology The Department of Bioinformatics and Biostatistics of the College is the first communication unit for this article.
Gao Yanxiao, a doctoral student at Sun Yale University, DeAnne Turner, a postdoctoral fellow at Yale University, Dr.
Frank Qian from Harvard Medical School, Professor Lu Hui from Shanghai Jiaotong University, and Professor Sten H.
Vermund from Yale University are co-authors.
The main work of the study was completed by the two co-first authors at the undergraduate level.
The study used meta-analysis to integrate existing empirical evidence to study the relationship between HIV infection and cognitive impairment in the elderly.
With the popularization of highly active antiretroviral therapy (HAART), HIV-related mortality has been greatly reduced, and the average life expectancy of HIV-infected persons (PLWH) has also been extended.
The number of elderly PLWH is on the rise, which is related to age Comorbidities (including increased risk of cognitive impairment) have become the main focus of HIV care.
Some existing studies have found that HIV may damage neurons and cause HIV-related neurological diseases (HAND) or HIV-related dementia (HAD), but ART treatment may reduce the incidence of HAD and cause mild neurocognitive impairment (MND) The high morbidity rate.
Both aging and HIV infection (that is, the medical side effects and neurological effects of long-term HIV infection) may adversely affect the cognitive health of elderly PLWH, and HIV infection may also have different effects on specific cognitive domains.
Prior to this, few articles specifically studied the cognitive impairment of PLWH and the performance of various cognitive domains for the elderly.
The results of this study show that compared with controls without HIV infection, elderly PLWH are more likely to develop cognitive impairment (OR=2.
44), and are more likely to have cognitive impairment in executive function, processing speed, language, recall, and motor/psychomotor.
The domains are significantly different.
The number of elderly PLWH is on the rise, which is related to age Comorbidities (including increased risk of cognitive impairment) have become the main focus of HIV care.
Some existing studies have found that HIV may damage neurons and cause HIV-related neurological diseases (HAND) or HIV-related dementia (HAD), but ART treatment may reduce the incidence of HAD and cause mild neurocognitive impairment (MND) The high morbidity rate.
Both aging and HIV infection (that is, the medical side effects and neurological effects of long-term HIV infection) may adversely affect the cognitive health of elderly PLWH, and HIV infection may also have different effects on specific cognitive domains.
Prior to this, few articles specifically studied the cognitive impairment of PLWH and the performance of various cognitive domains for the elderly.
The results of this study show that compared with controls without HIV infection, elderly PLWH are more likely to develop cognitive impairment (OR=2.
44), and are more likely to have cognitive impairment in executive function, processing speed, language, recall, and motor/psychomotor.
The domains are significantly different.
The public health significance of this study is that the results of this study provide a better understanding of the cognitive status of elderly PLWH, especially those cognitive domains that perform significantly worse in PLWH.
Therefore, in the elderly PLWH, we should not only pay attention to the HIV treatment itself, but also the potential cognitive decline.
Conducting cognitive tests will help early detection of cognitive decline in elderly PLWH, specific cognitive areas (such as executive Function, exercise/mental movement, processing speed, etc.
) can be targeted for treatment and cognitive training to improve the cognitive status and quality of life of elderly PLWH.
(Bioon.
com)
Therefore, in the elderly PLWH, we should not only pay attention to the HIV treatment itself, but also the potential cognitive decline.
Conducting cognitive tests will help early detection of cognitive decline in elderly PLWH, specific cognitive areas (such as executive Function, exercise/mental movement, processing speed, etc.
) can be targeted for treatment and cognitive training to improve the cognitive status and quality of life of elderly PLWH.
(Bioon.
com)
