Research finds vitamin K2 particles can improve bone health

The research team of Zheng Zhiming, a researcher at the Institute of Intelligence of the Hefei Institute of Material Science, Chinese Academy of Sciences , discovered that a vitamin K2 nanoparticle can effectively promote the differentiation of osteoblasts, thereby improving bone health.

Osteoporosis is a common debilitating bone disease, which is characterized by bone loss and bone structure degradation, mainly caused by the disruption of the balance between bone formation by osteoblasts and bone resorption by osteoclasts.

Vitamin K2 is the coenzyme of glutamate γ-carboxylase, which can carboxylate the glutamate residues in the vitamin K-dependent protein-osteocalcin and matrix γ-carboxylated glutamate residues.

In order to improve the bioavailability of vitamin K2, Zheng Zhiming's research group used amphiphilic carrier protein to hydrophilically modify vitamin K2.

Related paper information: org/10.