【Research News】Professor Luo Liang's team from the School of Life Sciences, Huazhong University of Science and Technology developed a Raman-traceable reactive oxygen species-responsive hydrogel for tumor surgery...

Immune checkpoint blockade (ICB) therapy has become the first-line therapy for many tumors, but its limited efficacy in "cold tumors" with insufficient immune cell infiltration has not been effectively resolved

In response to the above problems, the team of Professor Luo Liang of the National Nanomedicine Engineering Technology Research Center, School of Life Science and Technology, Huazhong University of Science and Technology, and Professor Sun Chunmeng of China Pharmaceutical University jointly developed a reactive oxygen species-responsive hydrogel for immunotherapy antibodies Protective delivery and sustained release in the presence of photosensitizers, and long-term synergy between photodynamic therapy and tumor immunotherapy

Professor Luo Liang's team previously reported a conjugated polymer polydiyne derivative PDDA that can be completely degraded under the action of reactive oxygen species (J.

In addition, the team's previous work also showed that PDDA has a super-strong Raman signal in the "cellular Raman silent region" (1800-2800cm-1), and its unit intensity can reach more than 105 times that of general small molecule probes (Nat.

The researchers further applied this reactive oxygen species-responsive hydrogel to a postoperative model of a typical "cold tumor" 4T1 tumor

The School of Life Science and Technology of Huazhong University of Science and Technology is the first unit of the thesis.

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